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Nuevo catalizador para la síntesis de cicloheptatrienos y sus derivados


Oferta Tecnológica
Tres centros de investigación españoles han desarrollado un nuevo catalizador para la síntesis de cicloheptatrienos y sus derivados. Los cicloheptatrienos son compuestos muy importantes para las industrias química y farmacéutica. Este nuevo catalizador ofrece un mayor rendimiento y selectividad en la obtención de cicloheptatrienos que los métodos existentes. Se trata de un catalizador reutilizable, estable y fácilmente escalable. Los cicloheptatrienos pueden emplearse en la síntesis de taxanos y rotaxanos, que son importantes componentes en la industria farmacéutica. También se utilizan como fragancias y precursores en la síntesis de polímeros. Los investigadores buscan socios con el fin de establecer acuerdos de licencia o cooperación técnica para continuar con el desarrollo.


New catalyst for the synthesis of cycloheptatriene and derivatives
Three Spanish research centers have developed a new catalyst for the synthesis of cycloheptatriene and its derivatives. Cycloheptatrines are very important compounds for chemical and pharma industries and this new catalyst allows their production with higher performance and selectivity than the existing methods. The new catalyst is reusable, stable and easily scalable. Researchers are seeking partners to reach license agreements or technical cooperation agreements for further developments.
Cycloheptatrienes and their derivatives are compounds with high potential in fine and pharmaceutical chemistry, but their use is limited due to the difficulties existing on their preparation. Unlike the classic 5 or 6 member cycles, widely used in industry, 7 member cycles have a high steric impediment and, consequently, very different chemical properties. This synthetic process is catalyzed so far with rhodium complexes in solution, which are very expensive, toxic and non-reusable.

Development of catalyst to outperform industrial process (like the synthesis of cycloheptatrienes) and technological advanced societies go hand by hand since the last two centuries. In this regard, subnanometric metal clusters attract the interest of the chemical industry because they show an extremely high catalytic activity and very good selectivity for different organic reactions. Despite some synthetic improvements, more efforts are required to synthesize these clusters in a controlled manner as well as to better determine their structure, nuclearity and shape in order to achieve better yields in catalysis.

Researchers from three Spanish public research organizations have developed a novel subnanometric catalyst for the synthesis of cycloheptatrienes.

The invention is applicable in industrial scale. Cycloheptatrienes can be used as a "building blocks" in the synthesis of taxanes and rotaxanes, which are very important compounds in pharmaceutical chemistry. Additionally, they can be used as fragrances, as well as precursors in the synthesis of polymers.

Researchers are seeking partners to reach license agreements or technical cooperation agreements to go on with the development of the technology.
Advantages and Innovations:
The synthetic procedure is simple and the solid catalyst is stable, thus, it can be recovered and reused repeatedly, maintaining its activity and catalytic selectivity. It allows the obtention of cycloheptatrienes in an easy way with a high performance and selectivity, with respect to the process existing until now. In this way, the catalytic system allows the production of cycloheptatrienes, with a price of around 10 euros per kg.

The main advantages provided by the invention are:

- Stability of subnanometric clusters: Due to its stability for the first time, it had been properly characterize.
- Reusable: without losing catalytic activity.
- One-stage procedure for the obtention of cycloheptatrienes and its derivatives (great variety) which simplifies the existing processes for the preparation of these products.
- Improves process performance and selectivity with respect to the state-of-the-art.
- Cost reduction: the catalyst operates in flow for hours allowing to recycle the solvent and is also reusable
- Easy process scalability: the simplicity of the process for preparing the catalyst allows an easy scale up of the production.
Stage of Development:
Under development/lab tested
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
Spanish patent applied for but not yet granted.
It is possible to apply for PCT

Partner sought

Type and Role of Partner Sought:
- Type of partner sought: companies or research centers
- Specific area of activity of the partner: with expertise in chemical and pharma sectors
- Task to be performed: The potential partners include pharmaceutical, drug development and fragrances industries and also enterprises in the specific area of catalyst, advanced materials, nanotech, etc., for licensing the invention, testing of applications, adaptation to specific needs, production and marketing.


Type and Size of Client:
Already Engaged in Trans-National Cooperation:
Languages Spoken:


Technology Keywords:
02007006 Fine Chemicals, Dyes and Inks
03004006 Organic Substances
03004007 Pharmaceutics
03004010 Special chemicals, intermediates