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Nuevo discriminador de masa para el sector médico


Oferta Tecnológica
Una empresa británica ha desarrollado un discriminador de masa de un solo uso del tamaño de una tarjeta de crédito que se utiliza como plataforma de diagnóstico en pacientes con diversas enfermedades, como diabetes, úlceras pépticas y disfunción del hígado. La tecnología es una alternativa a los grandes y costosos espectrómetros de masa comerciales y permite la detección precisa de pequeños grupos de sustancias. Se buscan socios para desarrollar soluciones específicas en distintos campos industriales y establecer acuerdos de licencia.


New Mass Discriminator for the medical sector
A UK company has developed a credit card sized, single use mass discriminator that could be used as a near patient diagnostic platform for several conditions such as diabetes, peptic ulcers and liver dysfunction. The technology developed scales down large and expensive commercial Mass Spectrometers yet permits accurate detection of small groups of substances. The company invites interested parties to develop single specific solutions in different Industrial sectors under a licence agreement.
A novel technology initially developed for the ESA's Rosetta Mission by a UK company, overcomes the two major issues faced by Mass Spectrometers (MS) - size and price. The innovative design comprises of two chambers, a sampling and analysis chamber separated by a rupture membrane, making the device a single use or disposable instrument. The electrode and magnet arrangement within the analysis chamber allow for the discrimination between a small number of ions, rather than identifying any ion species like the larger MS of the industry. The sample chamber may be an open or closed chamber. If closed, this may be by an admission valve arranged for the introduction of the required sample into the sample chamber.
One proposed application of the technology is in the field of medical diagnostics. The technology uses breath tests to diagnose medical conditions such as stomach ulcers; this will enable patients suffering from suspected stomach ulcers to be tested for species of bacteria called Helicobacter Pylori (H. pylori) at their doctor's surgery in minutes and with laboratory-standard accuracy, by the detection of Carbon 13 (C13) and Carbon Dioxide (CO2) exhaled by patients treated with C13 labelled urea. The bacteria breakdown urea into CO2 & ammonia, the latter allowing neutralization of stomach acidity for its survival. In order to accomplish this, the instrument needs to be able to discriminate between Carbon 12 (C12), CO2 and C13 CO2 in a breath sample.
H. pylori are the most common cause of stomach ulcers. It is estimated that more than a quarter of people in the UK become infected with the bacteria at some stage in their life. Unlike most other bacteria which are killed by the acid in our stomachs, H. pylori use the aforementioned technique to blanket itself from stomach acidity. The ulcers are a result of the lesions created by the attack of the body's immune response against the bacteria living in the mucosal membrane of the stomach lining.
To confirm their diagnosis many patients are currently referred to hospital. They are given a liquid to swallow, which is broken down by the H. pylori bacteria to produce a gas, and then have their breath tested to see if the bacteria is present using a large and expensive mass spectrometer. A breakthrough in this type of medical technology has been made that works in a similar way but is almost credit card sized, making it possible in the future for doctors to carry out these tests from their own surgery.
The technology could provide a simpler way of enabling both doctor and patient to find out what is wrong at the point of care and identify the best course of treatment much more quickly. Thus could reducing the burden on the national health services and free up many hospital appointments to be used for other medical conditions.
This technology is now offered to suitable partners who have the capacity to produce new condition monitoring devices for indicative symptoms and bring to market with the above as a model within a licensing agreement.
Advantages and Innovations:
Innovations are:
Many novel solutions were developed to achieve the miniaturization and reliability required for the instrument, including the use of shape memory alloys for the gas release mechanism and nanotechnology electron sources to build the world's smallest ion trap mass spectrometer.
Advantages are:
Portability is one of major advantages as the unit is about the same size of a credit card.
Disposable nature of the technology allows easy regulatory approval as well as reduced risk of cross patient contamination.
Stage of Development:
Already on the market
Patents granted
CommeR Statunts Regarding IPR Status:
UK and International patents in US, Japan, Spain and China

Partner sought

Type and Role of Partner Sought:
Ideal partners will have the capabilty to develop new applications for the symptomatic detection of diseases and medical conditions and have access to route to market.


Type and Size of Client:
Industry SME 50-249
Already Engaged in Trans-National Cooperation:
Languages Spoken:


Technology Keywords:
06001005 Diagnósticos, diagnosis
06001021 Productos de un único uso y bienes de consumo