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Nuevo enfoque terapéutico en una multiplicidad de enfermedades neurodegenerativas y autoinflamatorias

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOIT20190416001
Publicado:
07/05/2019
Caducidad:
07/05/2020
Resumen:
Un grupo de investigación italiano ha desarrollado nuevos enfoques terapéuticos de enfermedades neurodegenerativas y autoinflamatorias y busca socios para llevar a cabo investigaciones de enfermedades neurológicas. Las moléculas orgánicas pequeñas capaces de modular la activación del sistema inmune tienen un gran potencial en la identificación de un enfoque terapéutico para una multiplicidad de enfermedades neurodegenerativas y autoinflamatorias. La inhibición de la enzima caspasa-1 permite modular la liberación de citoquinas proinflamatorias a partir de la activación de la inflamasoma, bloqueando el proceso inflamatorio. Los socios buscados son compañías farmacéuticas, startups y otros grupos de investigación interesados en establecer acuerdos de colaboración en materia de investigación, cooperación técnica o financiación para desarrollos futuros.

Details

Tittle:
Novel therapeutic approach in a multiplicity of neurodegenerative and autoinflammatory pathologies
Summary:
An Italian research group has developed new therapeutic approaches to neurodegenerative and autoinflammatory pathologies. The research group is interested in finding partners for developing the research targeting neurological diseases. Partners may be pharmaceutical companies, startup or other research groups interested in research collaborations, in technical or research cooperation agreements or in financial agreements for future developments of a product.
Description:
Recent findings have highlighted the important role played by the disregulated activation of the innate immune system in the onset and progression of several neurological and autoinflammatory diseases. Small organic molecules able to modulate the activation of the immune system have, therefore, a great potential in the identification of a therapeutic approach for a multiplicity of neurodegenerative and autoinflammatory pathologies. The inhibition of the caspase-1 enzyme may allow to modulate the release of proinflammatory cytokines deriving from the activation of the inflammasome, blocking the inflammatory process. To date, there are no caspase-1 inhibitors that can be used in the clinic. In fact, although numerous caspase-1 inhibitors have been synthesized, no inhibitor has passed the clinical trial, probably because of the covalent mechanism of action and the consequent unwanted off-target interactions.
The research group, in collaboration with a foreign University, is interested in finding possible partners with whome to complete the pre-clinical study and further develop the technology through technical or research cooperation agreements or financial agreements.
Advantages and Innovations:
The research result and patent related, claims a new class of molecules able to inhibit caspase-1 to modulate innate immune system and in inflammatory processes. The new molecules discovered present innovative characteristics, with respect to the molecules currently known, because of their non-covalent mechanism of action.
Stage of Development:
Under development/lab tested
IPs:
Patent(s) applied for but not yet granted

Partner sought

Type and Role of Partner Sought:
Pharmaceutical companies interested in further developing the product.

Client

Type and Size of Client:
R&D Institution
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
Italian

Keywords

Technology Keywords:
06002002 Biología celular y molecular
06002009 Diseño molecular
06001002 Investigaciones clínicas, ensayos
06001014 Neurología, investigación cerebral