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Nuevo proceso de flujo continuo para preparar clorhidrato de metilfenidato

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOBE20170627001
Publicado:
25/08/2017
Caducidad:
25/08/2018
Resumen:
Una universidad belga ha desarrollado un nuevo proceso de flujo continuo para la preparación de clorhidrato de metilfenidato. Esta molécula, estimulante del sistema nervioso central, es un ingrediente activo en medicamentos recetados en todo el mundo (Concerta, Ritalin, Metadate, Methylin, etc.) para tratar el trastorno por déficit de atención con hiperactividad (TDAH) y narcolepsia. Se trata de un proceso seguro, limpio y rápido. La universidad busca socios con el fin de establecer acuerdos de licencia o investigación.

Details

Tittle:
Innovative continuous-flow process for the preparation of methylphenidate hydrochloride
Summary:
A Belgian research university has developed an innovative continuous-flow process for the preparation of methylphenidate hydrochloride. This molecule is the active ingredient of medication prescribed worlwide to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. The process is safer, cleaner and faster. A licence agreement or a research agreement are sought.
Description:
Methylphenidate hydrochloride, a central nervous system stimulant, is the active ingredient of medications such as Concerta, Ritalin, Metadate, Methylin,... that are amongst the most widely prescribed stimulant medications to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy (2,4 billion doses per year in 2013).
The methods used for the preparation of this molecule are mainly based on stepwise macroscopic batch processes which come with various shortcomings (poor mixing...) ultimately accounting for low productivity, quality deficiency and poor flexibility.
Besides, an increasing chemical risk is associated with classical large scale, stepwise batch processes, in particular when highly reactive species or hazardous/explosive intermediates are involved.

The Belgian research team patented the technology which relates to a scalable, safe and intensified continuous-flow process in micro/mesofluidic reactors for the production of methylphenidate hydrochloride. Besides, the patented invention provides various methods for synthesizing some specific pharmaceutically active species (reaction intermediates of methylphenidate synthesis), by using continuous-flow conditions with a drastically improved efficiency by comparison to the batch procedures.
The research team is looking for licence agreement and/or collaboration research agreement for development/optimization of continuous-flow production process(es) of other compound(s).
Advantages and Innovations:
The technology consists in an alternate more cost effective process to produce methylphenidate hydrochloride, or to synthetize any of its reaction intermediate:
.- overcomes the shortcomings of the batch processes : better mixing and heat transfer,
- accurate control on the reaction conditions, improved yield production and obtention of a product with a constant quality and purity profile
- safer process
- faster process (few minutes instead of few hours)
- cleaner process (minimal footprint)
Stage of Development:
Under development/lab tested
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
Worldwide patent application in preparation

Partner sought

Type and Role of Partner Sought:
Licensee partner who would like to produce methylphenidate hydrochloride by using the patented optimized continuous flow process.
Collaboration partner who would like to develop and/or optimized other continuous flow process for the production of other compounds on the basis of the patented production process.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
French

Keywords

Technology Keywords:
03004007 Pharmaceutics