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Nuevo sustituto de sangre con características reológicas similares a las de la sangre humana

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TODE20180801001
Publicado:
10/09/2018
Caducidad:
11/09/2019
Resumen:
Una universidad alemana ha desarrollado un nuevo sustituto de sangre que tiene características reológicas similares a las de la sangre humana y que se emplea como sustituto en caso de grandes pérdidas de sangre o como líquido de calibración en dispositivos de diálisis. Este sustituto se basa en una solución que contiene un polímero soluble en agua con un peso molecular de 100 kDa o superior. El polímero soluble en agua es preferiblemente una celulosa o derivado de celulosa con un alto peso molecular y cadenas flexibles. La universidad busca empresas interesadas en continuar con el desarrollo y lanzar el sustituto de sangre al mercado europeo. El objetivo es establecer acuerdos de licencia exclusivos y no exclusivos para la producción y distribución de la tecnología.

Details

Tittle:
New blood substitute with human blood characteristics.
Summary:
A German university has developed a new blood substitute, which owns similar rheological properties as human blood and can be used as a fluid replacement in the case of great loss of blood and as a calibrating liquid for dialysis devices. The university is looking for companies interested in further developing and bringing the substitute to the European market. Non-exclusive and exclusive licenses for production and distribution are sought-after; option agreements are possible.
Description:
The German university has developed a replacement solution for human blood, which can be used for replacing blood in patients after blood loss or for in-vitro studies, because it owns similar rheological properties like human blood.

At present, patients with great loss of blood get a physiologic salt solution that contains several polymers, which adjust the patient´s blood to a defined constant viscosity.

Blood analogue solutions are also widely used for in-vitro experiments as they exhibit several advantageous characteristics such as non-toxicity, low cost and transparency. However, since blood rheology is extremely complex, it is difficult to develop analogue fluids that yield a complete description of all the rheological properties of blood.

A number of fluids present rheological characteristics similar to human blood and are typically based on polymer solutions. These fluids are chosen based on the density and shear viscosity. The known blood analogue solutions suffer from the problem that the viscosity is essentially independent from the shear rate of the solution. In contrast, real blood exhibits a shear rate diminishing effect when viscosity increases.

A rheological blood replacement solution is provided and describes a method of its manufacture, its uses and pharmaceutical compositions based thereon.

It is based on a polymer solution that comprises a water-soluble polymer with a molecular weight of 100 kDa or greater. Preferably, the water-soluble polymer is a cellulose or cellulose derivative having a high molecular weight and flexible chains. It further contains compounds and additives that are described in details in the patent specification, which would be available upon request.

Limitations of the known polymer solutions are overcome, where the shear rate is independent from the actual viscosity of the fluid. It appears that the replacement of glycerine with polyethylene oxide is a major contribution in order to achieve these results. Consequently, at low flow rates, the polymer solutions of the prior state-of-the-art rather show Newtonian-like ("water similar") flow patterns, whereas the novel rheological blood replacement solution shows flow patterns similar to human blood.

This rheological blood replacement solution can be used in a variety of applications, e.g. as blood substitute, calibration agent or reference agent in clinical or analytical devices. It can also be used as pharmaceutical composition, e.g. for the prevention or treatment of haemorrhage or shock.

The university seeks companies interested in producing and distribution of the blood substitute under non-exclusive or exclusive rights, and would be willing to sign option agreements to allow previous evaluation.
Advantages and Innovations:
The innovation of the new blood substitute lies in its similar rheological qualities to human blood. The viscosity does not stay constant, but it adapts to the flow conditions in the blood vessels of the patient. Furthermore, it allows a more accurate calibration of dialysis devices.
Stage of Development:
Under development/lab tested
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
European patent application is pending.

Partner sought

Type and Role of Partner Sought:
The ideal partner is a company established in the medical or pharmaceutical market, and would be able to further develop the blood substitute as a marketable product.

Production and distribution would be possible under non-exclusive and exclusive licenses.

The university offers option agreements for prior testing and evaluation.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
German

Keywords

Technology Keywords:
06002002 Biología celular y molecular
06002001 Bioquímica / biofísica
06001011 Enfermedades circulatorias y del corazón
06002007 Ensayos in vitro, experimentos
06001007 Medicina de urgencias