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Nuevos antibióticos producidos por la actinobacteria abisal pseudonocardia carboxydivorans

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOES20160705002
Publicado:
07/07/2016
Caducidad:
07/07/2017
Resumen:
Un grupo de investigación español ha obtenido la patente de una nueva cepa bacteriana de pseudonocardia carboxydivorans capaz de producir de forma eficaz por fermentación compuestos antibióticos de la familia de las branimicinas. Esta cepa produce dos nuevas branimicinas y presenta actividad antibiótica o antibacteriana in vitro e in vivo frente a bacterias patógenas, preferiblemente humanas, tanto Gram-positivas como Gram-negativas. El grupo de investigación busca compañías en los sectores de microbiología y farmacia con el fin de desarrollar aplicaciones de la tecnología mediante acuerdos de licencia.

Details

Tittle:
Novel antibiotics produced by the abyssal actinobacterium Pseudonocardia carboxydivorans
Summary:
A Spanish research group has patented a novel bacterial strain of Pseudonocardia carboxydivorans which is able to efficiently produce by fermentation antibiotic compounds of the family of branimycins. Specifically, this strain is producing two new branimycins, having antibiotic or antibacterial activity in vitro and in vivo against pathogenic bacteria, preferably human. Companies in microbiology and pharmacy are sought to develop applications of the described invention under license agreements.
Description:
Marine environments are emerging as the source of novel natural products of pharmacological relevance, and deep-sea habitats are essentially unexplored sources for natural product discovery. Due to the increasing emergence of current antibiotic-resistant pathogenic bacteria, the development of new antibiotics with potential biomedical treatment or prevention of infectious diseases caused by pathogenic bacteria, both Gram positive and Gram negative, is necessary.

Researchers from a Spanish university and two hospitals working in microbiology provide a novel bacterial strain of Pseudonocardia carboxydivorans that has been isolated from its natural environment, which is able to efficiently produce by fermentation antibiotic compounds of the family of branimycins. Specifically, this strain is producing two new branimycins, having antibiotic or antibacterial activity in vitro and in vivo against pathogenic bacteria, preferably human, both Gram-positive and Gram-negative.

The present invention thus relates to a bacterial strain of Pseudonocardia carboxydivorans, to a supernatant or extract of a culture of such bacterial strain, to the use of the bacterial strain for the production of certain branimycins, to a process for obtaining said branimycins, to a pharmaceutical or cosmetic composition, to the manufacture of a medicament for the treatment and / or prevention of bacterial infections or for removal and / or prevention and / or inhibition of bacterial biofilm formation, preferably on inert surfaces, i.e. ex vivo.

The researchers would like to reach license agreements with companies operating in the clinical microbiology and pharmacy fields with the aim to develop applications of the described technology.
Advantages and Innovations:
The present invention represents a solution to the need for new antibiotic compounds with biomedical potential in the treatment or prevention of infectious diseases caused by pathogenic bacteria, both Gram positive and Gram negative, which are resistant to current antibiotics. It also represents a solution to the need for simple, short and economic procedures for obtaining said compounds with antibacterial activity as the method of the invention allows to produce the antibiotics by fermentation with actinobacteria, rather than by chemical synthesis, which is a more complex, lengthy and costly process. In this regard, in biotechnological processes involving obtaining structurally complex natural products, such in the case of branimycins, the production by fermentation using the producing microorganism is the preferred method because it is simpler, shorter and cheaper than the organic synthesis procedure.
Stage of Development:
Under development/lab tested
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
Patent applied for in Spain.

Partner sought

Type and Role of Partner Sought:
Type of partner sought: Industry.

Specific area of activity of the partner: Companies that operate in the clinical microbiology and pharmacy fields.

Task to be performed: Development of applications of the described invention under license agreements.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English
Spanish

Keywords

Technology Keywords:
06006 Biotecnología industrial
06002008 Microbiología
06001015 Productos farmacéuticos / medicamentos
06001018 Virus, virología / antibióticos / bacteriología