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Nuevos antimicrobianos potentes para aplicación en las áreas de bioconservación y dispositivos médicos

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOIE20151019002
Publicado:
23/10/2015
Caducidad:
22/10/2016
Resumen:
Un instituto de investigación irlandés busca socios comerciales en las industrias alimentaria y farmacéutica con el fin de continuar con el desarrollo y vender derivados superiores de bacteriocinas nisina. Estos derivados encuentran aplicación en bioconservación dentro del sector alimentario, así como en la industria de dispositivos médicos. Los derivados de nisina presentan una actividad antimicrobiana mejorada y también son activos en pH no ácido y efectivos no solo contra una amplia variedad de bacterias Gram positivas sino también contra algunas bacterias Gram negativas. Se buscan empresas para licenciar la tecnología.


Details

Tittle:
Novel potent anti-microbials for use in the of bio-preservation and medical device areas.
Summary:
An Irish Research Institute is seeking commercial partners within the food and pharmaceutical industries to further develop and commercialise superior derivatives of nisin bacteriocins, for applications in the food areas of bio-preservation and medical devices.

The Research Institute are interested in licensing out the technology to a commercial company.
Description:
Food grade derivatives of nisin A have been developed, and producers thereof, with greatly enhanced antimicrobial activity. This offers potential in a greater range of food products and other products within medical/ medical device areas, when compared to commercial nisin A.

Nisin A is an antimicrobial peptide which is used as a natural food biopreservative in over 50 countries. Nisin and nisin-producing food grade Lactococci are extensively used in food and is the only peptide to have been added to the European food additive list (E234) and approved by the US Food and Drug Agency (FDA) and World Health Organisation. Despite its success, its application is limited in some instances due to its relative inactivity against particular target species and strains and/or its poor activity at non-acidic pHs.

Recently developed food grade derivatives of nisin and its producers have been found to display greatly enhanced antimicrobial activity against problematic pathogenic and spoilage microbes. They are also active at non-acidic pHs and are effective not only against a broader range of gram positive bacteria but also some gram negative bacteria. With the added benefit of being effective at non-acidic pH, this ingredient has the potential to be applied in a greater range of food products. The availability of enhanced forms of nisin could result in the replacement of nisin A and make other applications a reality.

The Irish Research Institute is a well-established national body in the agri-food sector which supports science-based innovation and the wider bioeconomy. Suitable partners within the food and pharmaceutical industries are being sought through a licence agreement
Advantages and Innovations:
The following key benefits are provided;

1. Enhanced antimicrobial activity.

2. Active at non-acidic pHs.

3. Extended applications of nisin.
Stage of Development:
Under development/lab tested
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
Patent applications on the various nisin derivatives have been filed.

Partner sought

Type and Role of Partner Sought:
Seeking commercial partners within the food and pharmaceutical industries to further develop and commercialise superior derivatives of nisin bacteriocins, for applications in the food areas of bio-preservation and medical devices.

For example;
demonstration of safety of variants, demonstration of shelf life extension properties, development of food grade applications and scale-up manufacturing.

Client

Type and Size of Client:
R&D Institution
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English

Keywords

Technology Keywords:
08003 Micro y nanotecnologías relacionadas con la alimentación
06002008 Microbiología
06001018 Virus, virología / antibióticos / bacteriología