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Nuevos compuestos basados en escuaramida contra la enfermedad de Chagas y leishmaniasis

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOES20170921001
Publicado:
27/09/2017
Caducidad:
27/09/2018
Resumen:
Un equipo de investigación multidisciplinario de una universidad española ha patentado una nueva familia de compuestos con propiedades antiparasitarias. Estos compuestos son más estables, menos tóxicos y más baratos de producir que los medicamentos que se emplean en la actualidad. Sus principales ventajas son la baja toxicidad frente a células Vero, los altos ratios de efectividad contra las formas epimastigote y amastigote de los parásitos, la destacada disminución (>97%) en la reactivación de la parasitemia en la fase crónica después de inmunosupresión en ratones y su estabilidad química. Se buscan compañías de los sectores farmacéutico y veterinario para licenciar la patente o establecer acuerdos de investigación y cooperación técnica para desarrollar y validar el producto como antiparasitario.


Details

Tittle:
New compounds (squaramide based) against Chagas and Leishmania
Summary:
A multidisciplinary university research group has patented a new family of compounds with antiparasitic properties. These compounds are more stable, less toxic and cheaper to produce than the drugs currently used. Companies in the pharmaceutical or the veterinary sector interested in a patent license or in a research or technical cooperation agreement for developing and validating the product as antiparasitic are being sought.
Description:
Chagas and Leishmania diseases caused by protozoan parasites are a paradigmatic example of an extended parasitemia with unmet medical needs. Current treatments based on old-featured benznidazole and nifurtimox are expensive and do not fulfil the criteria of effectivity and lack of toxicity devoid to modern drugs.

As a result of the multidisciplinary cooperation between chemical and parasitologist researchers of two Spanish universities, a new family of aminosquaramide compounds with demonstrated in vivo activity against Chagas and Leshmania diseases has been developed. The chemical stability of these compounds together with the use of affordable starting products, and the lack of synthetic complexity put amino squaramides in the pole position toward the development of true low cost anti-parasitic agents.

The main application of the technology is a pharmaceutical composition for the treatment of human/animal parasitic diseases.

The researchers have determined the biological activity and the curative effects on murine models, but the next steps to be taken in the project are the hit to lead process, the target validation and the toxicological and ADME profile determination. Companies interested in advancing the project for developing the new antiparasitic product -through a licence or a research or technical cooperation agreement, are being sought.
Advantages and Innovations:
The main advantages are their low toxicity in front of Vero cells and high effectivity ratios against the epimastigote and amastigote forms of the parasites. Also, the remarkable decrease (>97%) in the reactivation of parasitemia in the chronic phase after immunosuppression in mice and their chemical stability, affordable starting materials and straightforward synthesis.
Stage of Development:
Under development/lab tested
IPs:
Patents granted
CommeR Statunts Regarding IPR Status:
The synthesis and the use of these compounds are protected by a Spanish patent.

Partner sought

Type and Role of Partner Sought:
Company in the pharmaceutical area for parasitic diseases, for licensing the invention or interested in a research or technical cooperation agreement.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English
Spanish

Keywords

Technology Keywords:
07001009 Medicina veterinaria
06001015 Productos farmacéuticos / medicamentos
05001004 Química orgánica