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Nuevos polímeros molecularmente impresos (MIP) específicos de biotina con numerosas aplicaciones en química, biología e ingeniería

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOUK20140411003
Publicado:
27/03/2015
Caducidad:
07/05/2015
Resumen:
Un investigador de una universidad británica ha desarrollado un nuevo polímero molecularmente impreso (MIP) que presenta alta afinidad a biotina, una vitamina necesaria para el crecimiento celular. Estos polímeros se emplean en una amplia variedad de sectores, desde sensores, descubrimiento de fármacos y administración controlada de medicamentos hasta catálisis enzimática. Se buscan socios industriales o investigadores con el fin de establecer acuerdos de licencia y desarrollo o para buscar nuevas aplicaciones de los polímeros.

Details

Tittle:
Novel biotin-specific Molecularly Imprinted Polymers (MIPs) with a range of chemical, biological and engineering applications
Summary:
A UK university researcher has developed an innovative Molecularly Imprinted Polymer (MIP) which has a high affinity with biotins, a vitamin necessary for cell growth. MIPs are used in a range of sectors, including sensing, drug discovery, targeted drug delivery and for providing enzyme-like catalysis. The researcher is seeking industrial or research partners for licensing opportunities or to test the MIPs towards new applications.
Description:
In medical, food, environmental and chemical sciences, there is an increasing need for the selective separation of specific substances from complex mixtures of related substances. Current methods for selection, recognition and capture of compounds include the use of enzymes, antibodies, DNA and other biologically active compounds. While the use of biological capture molecules is preferred due to their high selectivity and affinity for their target, the use of such molecules is usually lengthy, expensive and often difficult to reproduce and repeat on a large scale. The use of synthetic alternatives has been investigated, an example of which is Molecularly Imprinted Polymers (MIPs). An MIP is a polymer that has been prepared using molecular imprinting which leaves cavities in a polymer matrix with affinity to a chosen "template" molecule. The process usually involves initiating the polymerisation of monomers in the presence of a template molecule that is extracted afterwards, thus leaving complementary cavities behind. MIPs usually exhibit a high selectivity towards their substrate, analogous to antibody-antigen recognition and sufficient affinity for the original, template molecule. A fast and cost-effective molecularly imprinted polymer technique has applications in many fields of chemistry, biology and engineering. (e.g. MIPs are known as affinity material for sensors, detection of chemical, antimicrobial and dye residues in food, adsorbents for solid phase extraction, binding assays, artificial antibodies, chromatographic stationary phase, catalysis, chemical separations, drug development and screening, and by-product removal in chemical reaction). The technique has shown promise in chiral separations of, e.g. amino acid derivatives, peptides, phosphonates, aminoalcohols and beta-blocking compounds, affinity chromatography of nucleotides and the DNA-bases, as well as substitutes for antibodies in immunoassays for commercial drugs.

Biotin (known as vitamin H/B7) is necessary for cell growth, the production of fatty acids and the metabolism of fats and amino acids and is well-known to bind to the proteins streptavidin and avidin with one of the highest affinities known (Kd ca. 10-14 to 10-15 M). The strength of this interaction is used extensively in biochemical assays.

However Biotin belongs to a class of compounds for which the generation of MIPs remains problematic. Previous attempts to develop biotin-specific MIPs, have used methacrylic acid (MAA) as functional monomer. While MAA does undoubtedly lead to MIPs demonstrating high affinity for their targets, these high affinity binding sites tend to be in short supply. Non-specific binding can also be a problem for anything other than (trace) analytical applications. Non organic-based monomers have also been used for biotin recognition of MIPs but, these materials tend to be pH-dependent. The researcher has developed new functional monomers however, which can ensure structural stability and high affinity for biotin.
Advantages and Innovations:
The researcher's work concerns the development of new monomers and the subsequent generation of novel MIPs, specific for biotin. Of note is the fact that these functional monomers are prepared from two different building blocks, contrary to other monomers. That renders the resulting MIP to possess increased stability and binding capacity for biotin. Furthermore, the new monomers are used stoichiometrically (e.g. 1:1) with respect to the template (biotin) species and so, when polymerized, the resulting polymer has a large proportion of uniform binding sites, with high affinity for biotin and its derivatives.

Generally, MIPs offer a number of advantages compared to natural receptors and antibodies. These include high mechanical, thermal and chemical stability, excellent operational and storage stability, simplicity of manufacturing and comparatively low price for material preparation. MIPs work as artificial, man-made receptors and hence, they can easily be designed against a wider range of biological substances compared to naturally occurring receptors.

Stage of Development:
Under development/lab tested
IPs:
Patents granted
CommeR Statunts Regarding IPR Status:
Patents granted in European countries, the US and China.

Partner sought

Type and Role of Partner Sought:
- Type of partner sought: Industry or research centre

- Specific area of activity of the partner: Industrial chemists, pharmaceutical companies, R&D laboratories

- Task to be performed by the partner sought: Licensing or commercial agreement with technical assistance - to test the innovation for new applications

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English

Keywords

Technology Keywords:
06002001 Bioquímica / biofísica
06001005 Diagnósticos, diagnosis
06001015 Productos farmacéuticos / medicamentos
05001004 Química orgánica