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Placa multipocillo para ensayos de medicamentos basados en tejidos automáticos y fiables

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TODE20171107001
Publicado:
09/11/2017
Caducidad:
09/11/2018
Resumen:
Científicos de una universidad alemana han desarrollado placas multipocillo para ingeniería de tejidos y ensayos de medicamentos automáticos y fiables. La tecnología permite la producción fiable y constante de numerosos microtejidos humanos (por ejemplo, anillos del tejido muscular del corazón), la realización de ensayos automáticos de medicamentos y la monitorización dentro de la misma placa bajo SOP y GMP. La universidad busca socios especializados en automatización de laboratorios y fabricantes de instrumentos de laboratorio/proveedores de ensayos de medicamentos con el fin de establecer acuerdos de licencia.

Details

Tittle:
Multiwell plate for automated and reliable tissue-based drug screening
Summary:
Scientists at a German university developed multiwell tissue plates for automated and reliable tissue engineering and drug testing. This will allow for a reliable and consistent production of multiple human micro tissues (e.g. heart muscle tissue rings) and a subsequent automated drug screening and monitoring within the same multiwell plate under SOP and GMP. The university is looking for in-licensing partners active in lab automation, labware manufacturer/provider or drug screening provider.
Description:
The engineering of 3-dimensional (3D) tissue has undergone exciting progress for the past decade due to advances in human stem cell biology, tissue engineering and material sciences. Yet, preclinical compound or tox screenings still rely on 2D cell culture with poor predictive power. As tissue engineering from stem cells has matured and become more and more accepted, it has the capabilities to replace 2D-cell culture. Scientists at a German university developed a new device (multi-well tissue plate) for automated and reliable tissue engineering %26 drug testing.

Limitations of today´s 2D cell cultures have contributed to poor predictive power of preclinical cell-based drug and
toxicity screening assays. in fact, more than 90% of drugs that pass through in vitro preclinical studies fail to meet
the desired efficacy or safety required in subsequent clinical trials.
Due to recent advances in stem cell technologies, in vitro 3D cell culture (tissue engineering) have become
increasingly sophisticated and are now widely used in the research community. However, to become a powerful
and reliable tool in preclinical tissue-based drug and toxicity screening, new procedures and devices for a
consistent and automated tissue engineering of multiple micro tissues as well as an automated screening have to
be developed.

The university is looking for in-licensing partners from the industry, especially companies working in lab automation, labware manufacturer or Provider or drug screening provider.
Advantages and Innovations:
- New 3in1 tissue culture multi-well plate combining three steps:
- Culturing %26 condensing of cells
- Maturating into a micro-tissue
- Automated drug or toxicological screening.
- Standardized growth of any type of self-condensing cell mixtures into a homogeneous ring-shaped tissue
(Organ-on-a-Chip).
- Screening %26 production of human micro tissue rings under GMP and SOP in combination with newly
developed serum-free production.
- Optimized for automated video analysis - simple, robust and reliable.
Stage of Development:
Prototype available for demonstration
IPs:
Granted patent or patent application essential
CommeR Statunts Regarding IPR Status:
A priority patent application has been filed.

Partner sought

Type and Role of Partner Sought:
- Type of partner sought: Industry.

- Specific area of activity of the partner: Companies working in lab automation, labware manufacturer or provider, drug screening provider.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
German

Keywords

Technology Keywords:
06001002 Investigaciones clínicas, ensayos
06001007 Medicina de urgencias