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Plataforma de detección de medicamentos

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOIT20140623002
Publicado:
23/06/2015
Caducidad:
31/12/2015
Resumen:
Una empresa italiana especializada en ensayos preclínicos para desarrollo de componentes, desde el descubrimiento hasta la optimización, ha desarrollado una plataforma de detección para analizar la toxicidad y actividad de medicamentos, el efecto apoptótico y la toxicidad mitocondrial en células primarias o líneas celulares. Todas las medidas se realizan mediante análisis citofluorimétrico y técnica de ELISA (ensayo inmunoabsorbente ligado a enzimas). La empresa busca socios con el fin de establecer diferentes tipos de acuerdos, especialmente de cooperación técnica e investigación.

Details

Tittle:
Drug screening platform
Summary:
An Italian innovative company, highly skilled in all preclinical stages of compound development, from discovery to lead optimisation, has developed a screening platform from which to assess toxicity and activity of drugs in primary cells, apoptic effect and mitochondrial toxicity.
The Italian company is open to several kinds of collaborations, and is especially interested in technical or research collaborations.
Description:
An Italian company committed to discover and develop innovative, first-in class, disease-modifying medicines that address the unmet medical needs in viral infections, cancers and inflammatory diseases and has developed a core platform of novel compounds from which to explore multiple opportunities in the field.
The screening platform developed is aimed at assessing toxicity and activity of drugs (small molecules), in all fields of application. Toxicity in primary cells, apoptic effect and mitochondrial toxicity can be assessed in primary cells (peripheral blood mononuclear cells from healthy donors), or in cell lines. Activity against HIV can be assessed in both activated and in resting/activated primary cells in order to measure the half maximal inhibitory concentration (IC50 values). Toxicity and antiproliferative capacity can be determined in cancer cell lines. All measurements are conducted through cytofluorimetric analysis and standardized Enzyme-Linked ImmunoSorbent Assay (ELISA) techniques.
Advantages and Innovations:
The screening platform developed by this Italian young and dynamic company devoted to research and development in the field of biotechnologies and virology, is unique and assays employing primary cells have been developed to reflect in vivo processes.
Stage of Development:
Under development/lab tested
IPs:
Patent(s) applied for but not yet granted

Partner sought

Type and Role of Partner Sought:
The company is looking for research centres or companies interested in adopting or implementing the platform through technical cooperation or research agreements.

Client

Type and Size of Client:
Industry SME <= 10
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
Italian

Keywords

Technology Keywords:
06002002 Biología celular y molecular
06002007 Ensayos in vitro, experimentos
09001002 Métodos e instalaciones de ensayo / análisis
06001018 Virus, virología / antibióticos / bacteriología