Con esta herramienta te facilitamos un acceso a todas las ofertas y demandas de tecnología europeas y a búsquedas de socios para participar en propuestas europeas de I+D publicadas en la red Enterprise Europe Network, pudiendo filtrar los resultados para facilitar las búsquedas más acordes con tus necesidades.

¿Quieres recibir estos listados de oportunidades de colaboración en tu correo de forma periódica y personalizada? Date de alta en nuestro Boletín

Para optimizar los resultados de la búsqueda, se recomienda utilizar términos en inglés.

(Poli)hidroxilados industriales mediante carboligación enzimática

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOES20180116001
Publicado:
02/05/2018
Caducidad:
03/05/2019
Resumen:
Un centro de investigación español, una universidad alemana y una compañía española con amplia experiencia en desarrollo de enzimas biocatalíticas para producción industrial sostenible han desarrollado variantes de la enzima FSA con quimio- y enantioselectividad mejoradas en reacciones de carboligación aldólica (formación de enlace C-C) para la obtención de productos (poli)hidroxilados de interés industrial, como éster de Roche o 4-cloro-3-hidroxibutanal, bajo condiciones respetuosas con el medioambiente. Se buscan socios industriales interesados en utilizar estas variantes enzimáticas y la metodología asociada para fabricar compuestos (poli)hidroxilados a escala industrial bajo una licencia de patente.

Details

Tittle:
Industrial (poly)hydroxylates by enzymatic carboligation
Summary:
A Spanish research institution, a German University and a Spanish company have developed FSA enzyme variants with improved chemo- and enantioselectivity in aldol carboligation reactions (single C-C bond formation) rendering (poly)hydroxylate products of industrial interest, such as Roche ester or of 4-chloro-3-hydroxybutanal, under environmentally friendly conditions.
Industrial partners are being sought to collaborate through a patent licence agreement.
Description:
(Poly)hydroxylate compounds and other related building blocks are high added-value chemicals for the production of market-demanding pharmaceuticals and fine chemicals.

Production of (poly)hydroxylate compounds often requires aldol carboligation reactions involving use of hazardous substances and amounts of energy. Development of enzymatic catalysts to carry out stereocontrolled and chemoselective aldol reactions under mild conditions offers a great potential to improve the chemical manufacturing of this type of compounds in compliance with the concept and principles of Green Chemistry. However, current methodologies present restricted substrate selectivity and produce byproduct formation and subsequent reactions that hamper their industrial use.

The Spanish and German entities have developed new variants of D-fructose-6-phosphate aldolase from E. coli (FSA) showing high catalytic activity in enantioselective aldol reactions and enabling the production of single (poly)hydroxylate compounds, thereby avoiding byproduct formation. These FSA enzyme variants efficiently catalyze single carboligations of a broad range of substrates (aldehydes and ketones).

Particularly interesting for valuable industrial applications are the syntheses, using these enzymes, of the Roche ester or of 4-chloro-3-hydroxybutanal, two key building blocks used for the production of high market value compounds such as statins and other natural products and pharmaceutical compounds.

The Spanish and German entities have broad experience in the development of biocatalytic enzymes for industrial sustainable production. They are searching for an industrial company interested in the use of these novel enzyme variants and the methodology associated to manufacture (poly)hydroxylate compounds at industrial scale under a patent licence agreement. Companies interested in this technology should carry out scale-up process to reach the market. The research entities could collaborate with the company in that project.

Advantages and Innovations:
FSA variants developed allow:
· Exclusive selectivity for the designed single aldol addition, avoiding the formation of byproducts.
· Large structural variety of nucleophilic and electrophilic starting materials can be used, especially simple aliphatic ketones and aldehydes.
· Capacity to obtain building blocks and products difficult to obtain by conventional chemical methods.
· High simplicity and adaptability, with room for on-demand optimization.
Stage of Development:
Available for demonstration
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
European patent application filed in April 2017

Partner sought

Type and Role of Partner Sought:
- Partner sought: Industrial producers of fine chemicals and pharmaceuticals to develop and commercialize the technology through a patent licence agreement.

- Tasks to be performed by the partner: scale-up and industrial manufacture of (poly)hydroxylated compounds, as intermediate or final products, using the enzymatic catalysts and the methodology developed.

Client

Type and Size of Client:
R&D Institution
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English
German
Spanish

Keywords

Technology Keywords:
02007006 Fine Chemicals, Dyes and Inks
03004006 Organic Substances
02007014 Plastics, Polymers
03004010 Special chemicals, intermediates
06002003 Tecnología de enzimas