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Primer test de un biomarcador para el diagnóstico de la osteoartritis

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TODE20180515001
Publicado:
25/05/2018
Caducidad:
26/05/2019
Resumen:
Una universidad alemana ofrece autoanticuerpos para mejorar el diagnóstico de la osteoartritis. Se trata del primer test de un biomarcador en suero en este contexto. Este test también ofrece una herramienta para monitorizar el éxito terapéutico de medicamentos candidatos en el tratamiento de la artrosis. La universidad busca socios del sector de diagnósticos médicos con el fin de establecer acuerdos de licencia y cooperación técnica, ya que el biomarcador se encuentra en fase de desarrollo temprano y es necesario desarrollar un test de rutina operativo.

Details

Tittle:
First biomarker test for the diagnosis of osteoarthritis
Summary:
A German university offers autoantibodies that improve the diagnosis of osteoarthritis. It is the first serum biomarker test in this context. Partners from the medical diagnostic industry are sought for license agreements as well as a technical cooperation agreement.
Description:
Osteoarthritis (OA) is the most common degenerative disease of joints world-wide. About two-third of people over 65 years are affected, whereas the etiology is largely unclear. Currently, there is no causative therapy available, which is due to the complex pathomechanisms of arthrosis and also due to the lack of diagnostic biomarkers that allow monitoring of therapeutic success of drug candidates.

Researchers of a German university have found that autoantibodies against the cartilage protein thrombospondin 4 (TSP-4) occur in the course of arthrosis. Rheumatoid arthritis is characterized by the presence of autoantibodies, but autoantibodies against TSP-4 have not yet been described for arthrosis.

In addition to TSP-4, the researchers have found autoantibodies against the cartilage oligomeric matrix protein (COMP) and the C-type lectin domain family 3 member A (CLEC3A) in the course of OA, which may be used in a combined test together with TSP-4 in order to strengthen significance of diagnosis (Table 1). Thus the present invention is the first serum biomarker test that helps to support the clinical diagnosis of OA.

The university offers a license agreement to companies in the medical diagnostic sector. The university also offers a technical cooperation agreement because the biomarker is in an early development stage and needs to be develeoped into an operable routine test.
Advantages and Innovations:
The present invention is the first serum biomarker test that helps to support the clinical diagnosis of OA and furthermore it may provide a tool that allows the monitoring of therapeutic success of drug candidates for the treatment of arthrosis.
Stage of Development:
Field tested/evaluated
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
A European patent has been filed.

Partner sought

Type and Role of Partner Sought:
The university offers a license agreement to companies in the diagnostic sector (analysing blood) or companies offering supplies/ materials for blood analysis. The biomarker is in an early development stage and further patient trials need to be done. Hence the university also offers a technical cooperation agreement in order to develop the existing test into an operable routine test.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
German

Keywords

Technology Keywords:
06001005 Diagnósticos, diagnosis
06002008 Microbiología
06001013 Tecnología médica / ingeniería biomédica