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Procesos realizados en reactores enzimáticos

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOUK20150923001
Publicado:
07/01/2016
Caducidad:
07/01/2017
Resumen:
Una universidad británica ha desarrollado una nueva tecnología de intensificación de procesos enzimáticos que acelera la velocidad de reacción de una enzima. El reactor desarrollado se basa en los principios del reactor convencional de disco giratorio (SDR) y utiliza fuerzas centrífugas para esparcir una película delgada en un disco horizontal giratorio. Se buscan socios industriales en las áreas de síntesis de biodiésel, reacciones farmacéuticas, reacciones en cascada multicatalíticas y reacciones a alta temperatura para continuar con el desarrollo y aumentar las aplicaciones del reactor de enzimas. El objetivo es establecer acuerdos de cooperación y comercialización con asistencia técnica.

Details

Tittle:
UK university seeks technical cooperation with bio tech and pharmaceutical industrial partners for new enzyme reactor processes
Summary:
The UK university has developed a new enzymatic process intensification technology that accelerates the rate of an enzyme reaction. They are seeking technical cooperation / commercial agreement with technical assistance with industrial partners who can contribute to the further development and industrial application of the enzyme reactor.

Description:
The enzyme reactor developed by the UK university, is based on the principles of the conventional Spinning Disc Reactor (SDR), and uses centrifugal forces to allow the spread of a thin film across a spinning horizontal disc; however this disc has a cloth with immobilized enzyme resting on top of it.

This SDR therefore produces a flow of thin film both on top of, as well as through the enzyme-immobilised cloth, providing a large interfacial surface area for the reaction. The cloth is critical to increasing the potential of immobilized enzymes in a variety of reactions, since it should produce accelerated reaction rates due to high mass transfer rates and rapid mixing on top and within the cloth, with the cloth potentially helping protect the attached enzymes from excessive hydrodynamic forces.

This system produces enhanced reaction rates compared to conventional enzyme reaction systems.

The university is currently looking at biodiesel synthesis, pharmaceutical reactions, multicatalysis cascade reactions and high temperature reactions to extend the applications of this technology. Therefore they are seeking technical cooperation / commercial agreement with technical assistance with industrial partners operating in these areas.
Advantages and Innovations:
Many enzyme reactors suffer from a loss of enzyme activity over many cycles of reaction due to deactivation - this would be expected to be the case in a rotating reactor, where enzymes would be deactivated by shear.

However, the most exciting result is that the immobilized lipase has shown excellent stability to repeat reactions with the new SDR technology: for the tributyrin system, 80 per cent of the original lipase activity was retained after 15 consecutive runs.

The university team has also demonstrated the robustness of the new SDR technology to industry relevant feeds through the successful hydrolysis of different vegetable oils at reaction rates five times higher than other reactors.

Furthermore, a residence time distribution and flow analysis study showed that the new SDR technology is not quite like other rotating reactors - such as conventional spinning disc reactors and rotating packed bed reactors.

Results have shown that the new SDR technology is a separate class of spinning disc-type reactor for process intensification. They have called this new reactor class ´spinning mesh disc reactors´ (SMDRs), which enables any type of mesh (i.e. not just cloths) with an unbound top surface on a spinning disc to be included within this new reactor classification.

Overall, results indicate that the new SDR technology is an innovative, superior and robust technology for enhancing enzyme reactions, taking enzyme reactors beyond the current state-of-the-art. This concept can readily be extended to other enzyme-catalysed reactions, where enhanced mass transfer and enzyme stability is needed.
Stage of Development:
Under development/lab tested
IPs:
Other
CommeR Statunts Regarding IPR Status:
IPR not considered by the university at this point

Partner sought

Type and Role of Partner Sought:
The UK university seeks technical cooperation agreements or commercial agreements with technical assistance with organisations who would wish to apply this technology as an industrial application for pure research or for commercial opportunities.

The partner should be willing to cooperate with the university on further technical development for future application in industrial processes. The university does not seek to license out the technology and therefore an open agreement could be reached.

Partners should be in the areas of biotechnology, pharmaceutical or chemical processing.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
Danish
English
French
Norwegian
Swedish

Keywords

Technology Keywords:
06006012 Bioprocesos
03004007 Pharmaceutics
03004010 Special chemicals, intermediates
06002003 Tecnología de enzimas