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Producción de antioxidantes en plantas (vitamina K y E) para productos sanitarios o cosméticos

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOCH20160202001
Publicado:
19/02/2016
Caducidad:
19/02/2017
Resumen:
Una universidad suiza ha desarrollado una tecnología para modificar los procesos de producción de vitaminas de origen vegetal y acumular vitamina E y K o sus provitaminas en compartimentos de células fácilmente extraíbles. La universidad busca socios interesados en desarrollar productos comerciales que contengan vitaminas; específicamente busca fabricantes de productos sanitarios y cosméticos para establecer acuerdos de cooperación técnica o investigación. Los socios buscados deben tener capacidad para validar el método en productos dermatológicos y nutracéuticos.

Details

Tittle:
Antioxidant production in plant (vitamin E and K) for healthcare or cosmetic products
Summary:
A Swiss university developed a technology to modify plant vitamin production pathways to accumulate vitamin E and K or their pro-vitamins in easily extractable cell compartments. Partners interested to develop commercial products containing vitamins, in particular manufacturers of healthcare and beauty products are sought for technological or research cooperation. They should have the capacity to validate the method for e.g. dermatological products, neutraceuticals and to scale-up the method.
Description:
When exposed to high-energy light (e.g. UV) living organisms accumulate highly reactive oxygen species (ROS) in their tissues. If not contained ROS cause severe tissue damage and have long been recognized to contribute to tissue ageing and tumor progression.
To limit the damage caused by ROS, plants increase their levels of soluble antioxidants such as tocopherols (vitamin E), phylloquinone (vitamin K), and other prenylquinones which accumulate in lipid-based cell compartments, so called plastoglobules.

The university´s plant physiology experts have acquired a detailed understanding of the regulation and production pathways of vitamin E and vitamin K in plants with demonstrated hands-on experience in the control of these pathways in selected plants in such a way that accumulation of pro-vitamin K1, vitamin E as well as other antioxidants such as plastoquinone and plastochromanol in plastoglobules can be stimulated and easily retrieved from plant extracts.
By deleting key components of the vitamin K metabolic pathway, the university´s plant physiology experts have generated Arapidopsis sp. plant lines, which accumulate pro-vitamin K1 in plastoglobules. Using a simple centrifugation step, these pro-vitamin K1 enriched plastoglobules can be retrieved from plant extracts and, if wished, directly added to the product.
Similar methods have been developed to stimulate the accumulation of vitamin E as well as plastoquinone and plastochromanol in genetically-modified plants.
Beneficial antioxidant effects can be harnessed in dermatological or nutraceutical products containing these plant-derived compounds.

The method is at the experimental stage and the university researchers are looking for industrial partners to assist in the advancement of the plant-based production and extraction of overexpressed pro-vitamin K1 and other prenylquinones from cultivated plants or algae.
The Swiss university is interested in research or technical cooperation with industry to validate and to commercialize the technology, especially in the neutraceutical and cosmetic area.
Advantages and Innovations:
- Hands-on experience in modification vitamin K and E production pathways in plants
- Simple extraction procedure
- Natural production of antioxidants
Stage of Development:
Under development/lab tested
IPs:
Secret Know-how

Partner sought

Type and Role of Partner Sought:
The specific area of activity of the partner:
Producers (SME or industry) of neutraceuticals or cosmetics sectors.

The tasks to be performed by the partner sought:
- Validation of suitability of existing methods for topical application or as neutraceutical in the beauty and healthcare sectors
- Adaptation and upscaling of existing methods (production and extraction) to meet industrial conditions
- Exploration of further commercial opportunities for plant-based vitamin and pro-vitamin production
- Co-development of new methods

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English
French
German

Keywords

Technology Keywords:
03004011 Care, Hygiene, Beauty
06001 Medicina, salud humana
03004007 Pharmaceutics
06001015 Productos farmacéuticos / medicamentos
03004010 Special chemicals, intermediates