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Pymes finlandesas de diagnóstico ofrecen herramientas de química y detección con tecnología de nanopartículas de upconversión para licencia

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOFI20161007001
Publicado:
18/10/2016
Caducidad:
18/10/2017
Resumen:
Un grupo de pymes finlandesas ha desarrollado herramientas de química y detección con tecnología de nanopartículas de upconversión para licencia. Las nanopartículas convierten la radiación de infrarrojo cercano en luz visible mediante un proceso único que permite medir la fotoluminiscencia sin autofluorescencia ni luz de excitación dispersa. Las nanopartículas son cristales inorgánicos de 35 nm dopados con dos tipos de iones lantánidos: Yb3 y Er3. La empresa busca socios en I+D con el fin de utilizar estas herramientas y sistemas de detección en el desarrollo de ensayos médicos, medioambientales y farmacéuticos.

Details

Tittle:
Finnish diagnostic SMEs offer their Upconverting Nanoparticles (UCNP) technology chemistry and detection tools for out-licensing
Summary:
Two Finnish SMEs have developed Upconverting Nanoparticles (UCNP) technology chemistry and detection tools and are now offering them for out-licensing. The companies are looking for development and research partners to utilize the UCNP technology chemistry tools and detection systems for healthcare, environment and pharma assay development. The cooperation is considered to be in the form of license agreement.
Description:
Two Finnish diagnostic industry SMEs have as a joint venture developed Upconverting Nanoparticles (UCNP) technology chemistry and detection tools. The companies have jointly accumulated a combined experience of more than 100 years in developing world leading assay development chemistries and detection tools both for research and In Vitro Diagnostic (IVD) use.

UCNP is a comprehensive concept built around a novel label technology known as photon upconversion. In this unique technology, upconverting nanoparticles (UCNPs) convert near-infrared (NIR) radiation to visible light via a unique process that enables the photoluminescence to be measured entirely free of autofluorescence and scattered excitation light.

UCNP particles are 35 nm sized inorganic crystals that are doped with two kinds of lanthanide ions, [Yb3 ] Ytterbium [Yb3 ] as sensitizer ion and erbium [Er3 ] as activator ion. The Yb3 ion absorbs an NIR photon and transfers the energy to Er3 , which stores the energy in a long lifetime intermediate state. This allows time for the second NIR photon to arrive and "pump" the energy to a higher energy state, after which a single high-energy visible light photon is emitted. This process requires considerably less excitation power than two-photon excitation [TPA] technology owing to the long-lived intermediate energy states of the lanthanide ions.

The UCNP particles are available either as "ready-to-use" labels with streptavidin coupling, or with an amine reactive surface for use in a specific application.

The developed UCNP detection system is a small footprint, versatile and compact multimode plate reader system, with excellent performance featuring UCNP measurement option and with an ability to be upgraded to contain other commonly needed reference detection modes. Assays and research parameters are easily modified utilizing the instrument own software and tests can easily be added to the instrument menu.

The companies are looking for development and research partners that would utilize the UCNP technology chemistry tools and detection systems for healthcare, environment or pharma assay development. The cooperation is considered to be in the form of license agreement.
Advantages and Innovations:
The UCNP particles provide several advantages such as the elimination of autofluorescence due to the NIR-excitation which enables the detection through tissue and even whole blood. The emission is bright, the bands are discrete and they have a long lifetime. When using UCNP particles no photobleaching or self-quenching is seen.

Research institutes developing various bioaffinity assays, SMEs or bigger companies in the life science field developing for example quantitative lateral flow for point-of-care environment, can improve their existing method with a new type of detection system based on UCNP particles and advanced instrumentation.

A small footprint, versatile and compact multimode plate reader, with excellent performance which is the first commercially available plate reader with an UCNP reading option. This new system brings the new UCNP technology into the life science laboratory. Consisting of UCNPs together with a unique microplate reader the system is the first of its kind in the world and offers many benefits over traditional label technologies. With UCNPs by converting near-infrared radiation (NIR) into visible light the emission signal can be measured free of auto-fluorescence and scattered excitation light. The emission signal comes from lanthanide ions being very stable with a long lifetime (from µs to ms). These two factors render the instrumentation simple, yet robust. This scientific collaboration results in the option of measuring up-converting nanoparticles. This offers a possibility to achieve a more than two orders of magnitude better signal to noise ratio versus traditional measurements preformed with Lateral Flow - gold particles.

· Autofluorescence eliminated
· Detection even through tissue and in whole blood
· Measurement without photobleaching or self-quenching

Ideal for
· bioaffinity assays
· quantitative lateral flow tests
· microscopy and imaging
Stage of Development:
Already on the market
IPs:
Patents granted

Partner sought

Type and Role of Partner Sought:
Experienced and networked clinical, diagnostic, environmental or pharma assay developer or determination technology expert looking for a novel improved technology solution.

Client

Type and Size of Client:
Industry SME 11-49
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English
Finnish
Swedish

Dissemination

Restrict dissemination to specific countries:
Austria, Belgium, Canada, Croatia, Czech_Republic, Denmark, Estonia, Finland, France, Germany, Ireland, Netherlands, Norway, Poland, Portugal, Spain, Sweden, Switzerland, United Kingdom, United States

Keywords

Technology Keywords:
06001005 Diagnósticos, diagnosis
06004 Micro y nanotecnología relacionada con las ciencias biológicas
06001013 Tecnología médica / ingeniería biomédica