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Revestimiento antimicrobiano para aplicaciones médicas mediante el uso de electrohilado

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOSG20171107006
Publicado:
07/11/2017
Caducidad:
07/11/2018
Resumen:
Un hospital de Singapur ha desarrollado un método de reticulación en un solo paso para fabricar revestimientos antimicrobianos duraderos no lixiviantes compatibles con diversos sustratos. Este método facilita el desarrollo de revestimientos protectores con agentes antimicrobianos, como iones metálicos, polímeros antisépticos catiónicos y antibióticos, sin perder las propiedades antimicrobianas y abarcando numerosos agentes infecciosos. El método utiliza polímeros biocompatibles y volubles en agua para generar nanofibras en un algodón o película polimérica mediante procesos de electrohilado, mejorando la durabilidad del revestimiento. El hospital busca pymes y centros de investigación con el fin de establecer acuerdos de licencia o investigación.

Details

Tittle:
Antimicrobial coating for healthcare applications using electro-spinning.
Summary:
A Singapore hospital has developed a one-step crosslinking method to manufacture durable, non-leaching antimicrobial coatings compatible with varied substrates. It facilitates the development of protective coatings with antimicrobial agents such as antimicrobial metal ions, cationic antiseptic polymers and antibiotics without loss of antimicrobial properties to target a broad range of infectious agents. The hospital seeks licensing or research partnerships with SMEs / research institutions.
Description:
The patented crosslinking method developed by the Singapore hospital uses water-labile and biocompatible polymers to generate nanofibers either on a cotton bandage cloth or on polymeric films via electrospinning processes, improving the durability of the resultant coating.

The antimicrobial components used were able to promote wound healing while preventing microbial colonization, unlike the commercially available antiseptics or wound dressings. The wide chemical diversity of the crosslinkers can increase the potential use of the antimicrobial coatings and the resultant medical devices in combating microbial colonization.

One of the primary application developed using the coating technology is an antimicrobial wound dressing, containing cationic polymers with potent antimicrobial properties that also promotes cell migration and proliferation. The active antimicrobial components possess anti-inflammatory properties, thereby reducing the adverse effects of pathogens to the tissues. The rapid fluid uptake and non-adherent properties of the dressings can potentially decrease the healing time and may be more cost-effective as well.

This application is currently in an advanced pre-clinical testing phase.

The hospital is interested in establishing license agreements and research cooperation agreements with partner from the healthcare industry, such as an SME of any size to commercialise the technology, or with a research institute for further R-Y-D.
Advantages and Innovations:
· The developed method can help enhance the durability and provide sustained antimicrobial protection. It also facilitates the incorporation of high molecular weight cationic polymers or antimicrobial peptides without loss of their antimicrobial/ antiseptic properties in the wound dressings and other antimicrobial solutions. Direct electrospinning of bandage gauze can also potentially overcome several difficulties associated with handling of current wound dressing technologies.

· In addition to antimicrobial dressings, the method can also be used to produce mineralized nanofibers with superior osteoconductive properties than widely used pristine collagen.

· Compared to conventional polymeric scaffolds, the antimicrobial coating and the resultant wound dressing offers multiple benefits such as low surface roughness, reduced aqueous wettability, increased mechanical properties and enhanced photoluminenscent properties.
Stage of Development:
Under development/lab tested
IPs:
Patents granted
CommeR Statunts Regarding IPR Status:
Patent is granted for Singapore. Technology is available for licensing.

Partner sought

Type and Role of Partner Sought:
The Singapore hospital seeks to work with SMEs of all sizes or research/healthcare institutions in a licensing or research cooperation agreement partnership.

The partner sought could be a healthcare institution or healthcare technologies provider.

Under a licensing agreement:
The partner can license the technology to offer as a product or service to their customers.

Under a research cooperation agreement:
The partner can undertake joint development with the Singapore hospital to offer to introduce new products to targeted markets/segments.

Client

Type and Size of Client:
R&D Institution
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English

Keywords

Technology Keywords:
02007024 Nanomaterials
02007014 Plastics, Polymers