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Sensitive biosensors for real-time measuring

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TODE20210729001
Publicado:
02/08/2021
Caducidad:
03/08/2022
Resumen:
A German university has developed a new method that makes biosensors faster and up to 10 times more sensitive than current ones. Applications are among others in diagnostics. The university offers a license agreement to industrial partners active in sensor production and diagnostics.

Details

Tittle:
Sensitive biosensors for real-time measuring
Summary:
A German university has developed a new method that makes biosensors faster and up to 10 times more sensitive than current ones. Applications are among others in diagnostics. The university offers a license agreement to industrial partners active in sensor production and diagnostics.
Description:
Biosensors are sensing elements equipped with biological components. They are thus detection elements (sensors) for measuring e.g. antibodies, enzymes, nucleic acids, organelles or cells. Biosensors also measure synthetic substances such as aptamers, molecularly imprinted polymers, macrocycles or synthetic peptides. They are used in biotechnological measurement technology.

A German university now developed a manufacturing process that makes small, compact biosensors faster and up to ten times mor sensitive than conventional sensors. They can be created affordably in a CMOS (Complementary metal-oxide-semiconductor)-compatible manufacturing process.

The sensor measures miniscule voltage potentials using a field-effect transistor and crossed nanowire structures. The field-effect transistor is surrounded by an impermeable border. Additionally, two crossed Si nanowires made of semiconducting materials, each with a source and drain contact with a means to apply voltage between each source and drain contact, are connected. The nanowires are insulated from the sample material by a dielectric layer along their surface. This layer has at least one attachment point (e.g., for functionalization layers) that can trap charge carriers on the nanowires or, conversely, release them. The two nanowires each have a triangular cross-section and are supplied with voltage from the substrate, allowing for the manufacture of a highly sensitive probe/biosensor when functionalization layers for the appropriate molecule are applied to the nanowires.

The university is looking for companies from the sensor industry, especially biosensor manufacturers or manufacturers of diagnostic devices, who are interested to make use of the invention within a licensing agreement. This can be combined with joint research if the company wishes to bring the invention to market readiness or to a higher technology level together with the university.
Advantages and Innovations:
This new method allows the manufacture of biosensors that are faster and up to 10 times more sensitive than conventional ones.

Other advantages are:
- CMOS-compatible
- Small design
- Allow real-time measuring
- Suitable for low-cost measuring applications
Stage of Development:
Prototype available for demonstration
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
The underlying technology was filed with the German Patent and Trademark Office. Patents have also been applied in the following countries: CN, JP, US, EP (DE, BE, FR, SE, GB, CH, AT, LI, NL).

Partner sought

Type and Role of Partner Sought:
The university offers license agreements to manufacturers of sensors or diagnostic devices. It will be posssible to further develop the technology to market readiness in cooperation with the university. The partner should then implement the solution and bring it to the market.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
German

Keywords

Technology Keywords:
06001005 Diagnósticos, diagnosis
06004 Micro y nanotecnología relacionada con las ciencias biológicas
06005002 Sensores y productos inalámbricos
06001013 Tecnología médica / ingeniería biomédica