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Servicios de modelización y simulación sanguínea en capilares y materiales biológicamente activos y transporte en las membranas celulares

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOLT20160401001
Publicado:
04/04/2016
Caducidad:
04/04/2017
Resumen:
Una pyme lituana ofrece servicios de modelización informática (creación de modelos) y simulación (método de Monte Carlo) de procesos de transporte de materiales biológicamente activos en capilares y membranas celulares. Los modelos también pueden aplicarse para el transporte de moléculas de medicamentos y nucleidos radiactivos que se inyectan en el cuerpo humano. La empresa busca socios industriales y centros de I+D con el fin de establecer acuerdos de comercialización, financiación o investigación.

Details

Tittle:
Lithuanian company offers blood modeling and simulation services in capillaries and biologically active materials as well as transport across cells´ membranes
Summary:
Lithuanian SME offers services for computer modeling (creation of models) and simulation (using Monte Carlo methods) of biologically active materials transport processes in capillaries and across cells´ membranes.
The models can be also applied to transportation of molecules of drugs and radioactive nuclides being injected to the human body.
Company is seeking for industrial partners, R-Y-D institutions for commercial, financial or research cooperation agreements.
Description:
Lithuanian small scientific research company is working in the following fields:
1) mathematical and computer modeling and simulation of physical and technological processes;
2) creation of mathematical and computer business (industry, construction, services, social) models, simulation of various scenarios, and preparation of detailed business plans based on modeling -Y- simulation results.
Project is devoted for the modeling and simulation of the following:
1) transport of the active biological materials (including carriers of radioactive nuclides) in blood media via capillaries;
2) transport across the cells´ membranes via different membrane transport channels;
3) further biochemical reactions´ kinetics in the cells (in the case of further project´s development).
The main idea is to switch from phenomenological kinetics to statistics of direct molecule-molecule, molecule-(cell membrane channel) processes. There have to be the dynamic picture of evolution of various molecules in time, space and their (molecules) internal structure change.
For the achievement of those purposes there have to be constructed the models of atom/ion (radioactive nuclide)-molecule, molecule-molecule, and molecule-(various cell membrane channels) interactions.
The ensembles of large amount of test molecules have to be taken for the simulations of their dynamical evolution.
The Monte Carlo methods (methods of stochastic simulation) will be used for the numerical simulations of all those processes.
Each process and object will be modeled by use of different approaches as follows:
1) original phenomenological models;
2) models based on interpolation and approximation of experimental data;
3) models based on different theoretical approaches;
4) numerical models;
5) hybrid models.
For the further simulations of evolution of molecules´ ensembles, those mathematical models have to have the simple mathematical forms, or in other cases they have to be interpolated via simple numerical expressions (for example - Pade approximation, etc.).
There will be created the sets of working models with different complexity and accuracy for each physical and biochemical process and object.
The "Final model" (an integrated model involving all processes and evolution of molecules´ ensembles) is dynamic, i.e. there is the permanent development phase (of project) giving the pictures of processes with different accuracy, but giving intermediate results in early phases of researches.
During the TO realization time there will be created a set of "Final models" with different levels of complexity. That R-Y-D strategy enables to shorten the products´ creation time.
There will be used high-level powerful programming language C++.
During this work the fully original special computer software (the features of transport of blood and injected biological/chemical/ionic materials in capillaries; complex transport across cell membranes; possible generation of new transport channels (or modification of existing) in cells´ membranes) will be created.
Using results of various scenarios of simulations the phenomenological kinetic coefficients of various kinetic processes will be calculated.
The simulation results (including all intermediate results for each process) will be compared with experimental and theoretical data being published in various journals, monographs and gotten via private communications.
Company is looking for partners being interested in above mentioned results/products.
The sought partners would be active in engineering, industry, business or researches.
Advantages and Innovations:
Current technological offer (TO) is oriented to the following:
1. Scientific knowledge:
1) creation of new original models of physical-chemical-biological processes taken place in transport of biological materials and radioactive nuclides in capillaries and across cells´ membranes;
2) test of existing models;
3) more deep understanding of processes via use of various theoretical approaches in modeling and simulation;
4) calculation of kinetic coefficients of traditional kinetic equations via use of results of numerical modeling and simulations.
2.Practical applications:
1) simulation of real drug transport in human body including further biochemical reactions in the cells;
2) creation of empirical numerical models (based on project´s simulations) for the fast estimation of various physiological situations in practice.
3) calculate the space and time distribution of injected radioactive nuclides and special active biological structures (for example drugs) in human body;
4) help in diagnostics and pharmacological treatment.
Cooperation/collaboration with pharmacological and medical engineering companies has to form the problems being top for them and having to be solved in the frame of current project (via direct modeling and simulation of problematic situations taken place in above mentioned fields).
Stage of Development:
Proposal under development
IPs:
Secret Know-how

Partner sought

Type and Role of Partner Sought:
Type of partner sought:
- industrial partners (large companies or SME), R-Y-D institutions from the fields of medical -Y- pharmacy, medical equipment manufactures to cooperate in developing specific software, to test and evaluate it.

Task to be performed by the partner sought:
- to test and evaluate software with a view to considering commercial, financial or research cooperation agreements.

Client

Type and Size of Client:
Industry SME <= 10
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English

Keywords

Technology Keywords:
06002001 Bioquímica / biofísica
01003006 Computer Software
06001011 Enfermedades circulatorias y del corazón
01003016 Simulaciones
06001013 Tecnología médica / ingeniería biomédica