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Sistema de administración de nanocomposites mucoadhesivos cargados de aceite esencial para el sistema gastrointestinal

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOTR20160127001
Publicado:
22/02/2016
Caducidad:
22/02/2017
Resumen:
Una universidad turca ha estado desarrollando tecnologías de encapsulación para aplicaciones de liberación controlada desde hace 10 años. La universidad busca socios con el fin de establecer acuerdos de fabricación, cooperación técnica e investigación para producir nanocomposites de chitosán cargados de aceite esencial para terapia de erradicación de helicobacter pylori. Esta tecnología permite encapsular aceites esenciales en microesferas basadas en chitosán que mejoran el perfil de liberación de medicamentos de manera controlada y prolongar el tiempo de gastrorretención para terapia de erradicación de helicobacter pylori, que es el factor patógeno principal en gastritis, úlcera péptica y dispepsia.

Details

Tittle:
Essential oil loaded mucoadhesive nanocomposite delivery system for gastrointestinal system
Summary:
A Turkish university is looking for manufacturing, technical and/or research cooperation agreement to produce essential oil loaded chitosan nanocomposites for "helicobacter pylori" eradication therapy. This technology allows encapsulating of essential oils in chitosan based microspheres that improve drug release profile with controlled manner and prolong the gastroretention time for "h.pylori" eradication therapy which is the major pathogenic factor in gastritis, peptic ulcer and dyspepsia.
Description:
A Turkish university has been developing encapsulation technologies for controlled release applications for 10 years. This technology comprises encapsulation of a bioactive agent (essential oil) in polymeric matrix for controlled release, bioavailability and patient compliance. Microspheres are produced by spray drying process so that easily scale-up and commercialization.

Initial studies comprise production of microspheres with uniform particle size distribution, drug release in gastrointestinal system, antibacterial effect against "h.pylori" and in vitro cytotoxicity -Y- biocompatibility assays. This product is designed as functional foods and pharmaceutical agents for "h. pylori" eradication in gastrointestinal system.
This technology could also be used for encapsulation of other active molecules (plant extracts, bioactive molecules, drugs).
The university offers:
- Know-how for encapsulation of bioactives
- Evaluation of biocompatibility and biological functionality for h.pylori eradication
The university is looking for manufacturing, technical and/or research cooperation agreement with:
- SME with drugs/bioactive molecules to encapsulate for oral administration
- Industrial partner for technology transfer/scale-up
Industrial applications: Manufacturing, technical and/or research cooperation with related field:
- Food and nutrition: Functional food or food supplement
- Pharma: Controlled release formulations
- Pharmaceutical coating excipient
Companies located in Germany, France, Spain and Netherlands will be preferable.

Advantages and Innovations:
Essential oil loaded mucoadhesive nanocomposite delivery system has the following advantages;

- Decreasing the side and toxic effects instead of synthetic drugs
- Antimicrobial activity against H.pylori
- Development of mucoadhesive gastroretentive system with controlled release of essential oil
- Biodegradable and non-toxic
- Enhancing gastric residence time and provide sustained release.
- Improvement bioavailability of essential oil
- Prevention adhesion of H.pylori to gastric mucosa with mucoadhesive chitosan and thus providing preventive therapy as well as eradication.
- Regeneration of damaged gastric tissue by chitosan and essential oil containing nanocomposite.
- Providing patient compliance and nutritional health support
Stage of Development:
Under development/lab tested
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
The patent cooperation treaty application is completed.

Partner sought

Type and Role of Partner Sought:
- Type of partner sought: SME, university, pharma and/or food industry
- Specific area of activity of the partner: encapsulation, pharma industry with controlled release formulations and herbal based products, food supplement, health sciences.
- Task to be performed by the partner sought: develop this approach/product and commercial production in food or pharmaceutical industry to put into marketing (or introduce this product into the market)
The university is looking for partners located especially in Germany, France, Spain and Netherlands.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English

Dissemination

Restrict dissemination to specific countries:
France, Germany, Netherlands, Spain

Keywords

Technology Keywords:
06001024 Biomateriales médicos
06002007 Ensayos in vitro, experimentos
06004 Micro y nanotecnología relacionada con las ciencias biológicas
02007024 Nanomaterials
03004007 Pharmaceutics