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Sperm stratification for the diagnostic of male infertility

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TODE20200721002
Publicado:
24/07/2020
Caducidad:
25/07/2021
Resumen:
A German university offers a new stratification technology to determine the sperm quality and assess the fertilization potential of humans and animals. Four different quality categories are provided by the new method. This information is relevant to diagnose male infertility and supports decisions on treatment opportunities. The university offers license agreements.

Details

Tittle:
Sperm stratification for the diagnostic of male infertility
Summary:
A German university offers a new stratification technology to determine the sperm quality and assess the fertilization potential of humans and animals. Four different quality categories are provided by the new method. This information is relevant to diagnose male infertility and supports decisions on treatment opportunities. The university offers license agreements.
Description:
Sperm DNA damage is prevalent among infertile men, becoming one of the most discussed and promising biomarkers for the assessment of male fertility. Unfortunately, the currently available methods for DNA evaluation do not distinguish between live or dead cells in terms of membrane integrity. Therefore, the extent of DNA damage among live spermatozoa, which are the ones used and wanted for assisted reproductive technologies (ART), remains unknown for clinical use. Thus, there remains a need in the art for a refined method of sperm stratification usable in clinics and research for fertility analysis.

A German university offers a technology that describes a method for stratifying human or animal spermatozoa. Combining simultaneous assaying for sperm membrane integrity and nuclear DNA fragmentation, the stratification method allows an analysis of four relevant sperm categories and assessment of fertilizing potential. A kit may provide standardization and quality control measures for easy application. The technology provides clinically relevant information for the diagnostic of male infertility and guides decision on treatment options. It thus adds new endpoints to diverse research fields e.g. reproductive physiology, sperm biology, germ cell function, fertilization and reprotoxicology.

Industrial partners, e.g. from the field of diagnostics, are sought for license agreements to implement the technology and take it to the market.
Advantages and Innovations:
· New method that associates levels of DNA fragmentation with vitality readout and provides four relevant categories for sperm quality
· More rapid, accurateand cost-effective than conventional methods
· Easy to apply method
Stage of Development:
Field tested/evaluated
IPs:
Patent(s) applied for but not yet granted

Partner sought

Type and Role of Partner Sought:
The university offers license agreements

· Type of partner sought: Provider of flow cytometers and/or sperm diagnostics

· Role of partner: Make use of the invention, further develop the invention and subsequently sell the product

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
German

Keywords

Technology Keywords:
06001005 Diagnósticos, diagnosis
06001012 Investigaciones médicas
06001009 Terapia genética - ADN