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Tecnología de hidrogeles peptídicos con capacidad de autoensamblaje para experimentos con células, ensayos, aplicaciones in vivo y andamios para ingeniería de células y tejidos

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOUK20151007002
Publicado:
26/11/2015
Caducidad:
26/11/2016
Resumen:
Una empresa británica especializada en diseño de hidrogeles peptídicos para aplicaciones biomédicas y biotecnológicas ha desarrollado una familia de hidrogeles basados en péptidos con capacidad de autoensamblaje. Estos hidrogeles tienen el potencial de imitar el microentorno de las células y ofrecen un espacio fisiológico natural para cultivos celulares en 3D. Los hidrogeles son fáciles de usar y pueden emplearse con fines de formación e investigación. Se buscan usuarios potenciales de hidrogeles para establecer acuerdos de licencia, joint venture o cooperación en materia de investigación.


Details

Tittle:
Peptidic hydrogel technology, with self-assembling feature, suitable for cell based experiments, assays, in-vivo applications as well as scaffolds for cell and tissue engineering
Summary:
This North West UK based company specialises in the design of peptide hydrogels for biomedical and biotechnological applications. They have developed a family of self-assembling peptide based hydrogels with potential to mimic cell microenvironment and can provide a natural physiological for 3-dimensional (3D) cell culture.

The company is looking to engage with potential users of hydrogels via licensing, joint venture or research cooperation agreements.
Description:
This research focused UK based SME specialises in bespoke design and use of animal free biocompatible and biodegradable hydrogels with tailored properties and functionalities. The hudrogels are suitable as scaffolds for cell based therapies and assays, drug delivery vehicles as well as tissue engineering, thereby enabling the next generation of therapeutic treatments. Their hydrogels come in 3 basic formats; sprayable, injectable or part of a system of composites.

As all cells are different, the company is commercialising a family of synthetic fully chemically defined hydrogel technological platforms based on the understanding of the self-assembling behaviour of short peptides in water. The proposed technology offers the ideal environment for cells providing those with a human relevant microenvironment.

Their systems have tuneable mechanical strength to suit a range of different cell types and can be functionalised with biological epitopes or formulated with small or large molecules such as growth factors.

The potential application areas are: primary and stem cell cultures, 3D cell culturing and directed differentiation, in-vitro biological system modelling, etc. The hydrogels are easy and ready to use, and are ideal for training and research purposes, from the bench to patient therapy development.

Key features:
- Physiological scaffold to mimic cell microenvironment
- No changes to user´s habits
- Compatible with all standard analyses (optical, electrochemical)

The company is keen to speak with organisations who are using or looking to use hydrogels either in the Life Sciences sector, diagnostic fields, medical device coating or those looking for a mucoadhesive vehicle for cells/biologics delivery in vivo.

The company is interested in engaging with potential partners via licensing, joint venture or research cooperation agreements.
Advantages and Innovations:
Life Sciences scientists and cellular therapy developers are looking for a cost effective reproducible technology platform whose features (mechanical properties, functionalities) can be easily tailored to their own specific needs.

This company offers a range of extracellular matrix (ECM)-like scaffolds, whose mechanical properties can be tuned between 0.5-50kPa hereby mimicking from soft to hard tissue environments. The standard products catalogues are delivered with a 10kPa shear modulus to fit most of cell scientist needs.

Their unique ready to use hydrogel scaffolds can be used as either standalone gels or pre-coated inserts so that end users do not have to worry about cell seeding matrix preparation. The translucency of the scaffolds also direct biological system characterisation via microscopy.

The porous scaffolds also allow direct extra cellular and intra cellular component characterisation, e.g. antibody/chemical staining without the need of cell manipulation as the peptidic scaffolds are porous and do not prevent staining agent diffusion throughout the scaffold.

Their hydrogels have been demonstrated in the field of multienzymatic biocatalytic systems as well as matrices for biomedical or environmental monitoring applications.
Stage of Development:
Already on the market
IPs:
Secret Know-how,Design Rights,Patent(s) applied for but not yet granted,Exclusive Rights

Partner sought

Type and Role of Partner Sought:
The company is looking for both:

· Public and private research organisations
· Hospitals or companies (SMEs, MNEs) from Life sciences, drug delivery or medical devices.

The cooperation types envisaged are licensing, joint venture or research cooperation agreements. The company is looking for long term collaboration as it´s a platform technology with multiple applications. If there is interest from research organisations or companies (SMEs, MNEs) who wish to use the technology for test purposes, then they will be dealt via commercial agreements with technical assistance.

Client

Type and Size of Client:
Industry SME <= 10
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English

Keywords

Technology Keywords:
06002002 Biología celular y molecular
06001024 Biomateriales médicos
06001012 Investigaciones médicas
06001013 Tecnología médica / ingeniería biomédica
06001019 Tecnologías de células madre