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Tecnología inocua de limpieza óptica de muestras biológicas

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TODE20160606001
Publicado:
13/06/2016
Caducidad:
13/06/2017
Resumen:
Una universidad alemana ha desarrollado una sustancia y protocolo para la limpieza óptica de muestras biológicas sin utilizar productos químicos perjudiciales. Esta sustancia permite que incluso personal de laboratorio sin experiencia pueda llevar a cabo el proceso de limpieza óptica de forma segura. La tecnología está indicada para proveedores o compañías del campo de microscopía y técnicas de imagen. La universidad busca socios con el fin de establecer acuerdos de licencia y cooperación técnica.

Details

Tittle:
Non-harmful optical clearing of biological samples
Summary:
A German university invented a substance and protocol that enables an optical clearing of biological samples without using harmful chemicals. By means of this substance a safe optical clearing can be done even by unpracticed laboratory personnel. The university offers a license agreement and is open for a further technical cooperation. This invention mainly addresses suppliers or companies in the field of microscopy and imaging techniques.
Description:
The latest developments in microscopy and imaging techniques (e.g. light-sheet microscopy, two-photon microscopy, optical projection tomography) facilitate the display of large three-dimensional tissue samples.
Refractive index matching of the biological sample with the surrounding medium is an established method for optical clearing of entire organs, whereas the key challenge is the preservation of fluorescence staining that has been performed beforehand. However, all of the currently established protocols are based on the use of harmful chemicals (ref. Richardson -Y- Lichtman).
The herewith presented invention by a German university substitutes these harmful chemicals by a non-harmful substance with comparable results of fluorescence preservation. By means of this substance, an easy to use protocol has been established that allows a safe optical clearing of biological samples for microscopy even by unpracticed laboratory personnel.
The university offers a license agreement and is open for a further technical cooperation.
Advantages and Innovations:
There is currently a strongly growing need for methods and chemicals for the preparation of large biological samples for three-dimensional imaging. The invention presented meets the chemical challenge by:
- First and only protocol for optical clearing that completely dispenses with harmful chemicals
- Clearing process fully preserves fluorescence-staining for high quality imaging
- Cheap and easy to use method
Stage of Development:
Field tested/evaluated
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
A patent application has been filed in the European Patent Office.

Partner sought

Type and Role of Partner Sought:
The university offers a license agreement and is open for a further technical cooperation. This invention addresses supplier or companies in the field of microscopy and imaging techniques.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
German

Keywords

Technology Keywords:
06002001 Bioquímica / biofísica
06001015 Productos farmacéuticos / medicamentos
05001001 Química analítica
05001004 Química orgánica