Con esta herramienta te facilitamos un acceso a todas las ofertas y demandas de tecnología europeas y a búsquedas de socios para participar en propuestas europeas de I+D publicadas en la red Enterprise Europe Network, pudiendo filtrar los resultados para facilitar las búsquedas más acordes con tus necesidades.

¿Quieres recibir estos listados de oportunidades de colaboración en tu correo de forma periódica y personalizada? Date de alta en nuestro Boletín

Para optimizar los resultados de la búsqueda, se recomienda utilizar términos en inglés.

Tecnología patentada libre de células para la producción de proteínas de membrana activas

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOFR20180822001
Publicado:
13/11/2018
Caducidad:
14/11/2019
Resumen:
Una empresa francesa especializada en la producción, purificación, formulación y caracterización de proteínas ha desarrollado y obtenido la patente de un proceso para producir proteínas de membrana funcionales estabilizadas en liposomas artificiales que forman proteoliposomas. Esta tecnología ayuda a académicos y farmacéuticos en todos sus proyectos y ofrece como principal ventaja la velocidad y la producción de una amplia variedad de proteínas. La tecnología libre de células ofrece soluciones a los principales problemas de expresión celular: cuerpos de inclusión, proteínas truncadas o proteínas inestables y citotóxicas, por ejemplo. La empresa busca socios con el fin de establecer acuerdos de investigación, cooperación técnica o comercialización con asistencia técnica.

Details

Tittle:
Patented cell-free technology for production of active membrane proteins
Summary:
A French Company in the field of production, purification, formulation and characterization of proteins has developed a patented process to produce functional membrane proteins stabilized in artificial liposomes forming proteoliposomes. This technology helps academics and pharmas in all their projects.The main advantage is speed and It can also produce a wide of proteins.
Partnership can be considered via research or technical agreement or commercial agreement with technical assistance.
Description:
Founded in 2011, the French Company is a French service provider or CRO (Contract Research Organisation), in the field of production, purification, formulation, and characterization of proteins.
The cell-free "technology" makes it possible to provide solutions to the main problems encountered with cellular expression: inclusion bodies, truncated proteins, unstable and cytotoxic proteins for example. From this technology, It is possible to express quickly and in quantity SIMPLE as DIFFICULT proteins. It can be membrane proteins in different formats: proteoliposomes, nanodiscs or solubilized.
With the help of academic or private teams, this technology allows for example to provide membrane receptors which are then used to select biologic candidates by phage display.
Partnership can be considered via research or technical agreement or commercial agreement with technical assistance. For example :

Via research or technical agreement :
- Any partner able to bring a technology or know-how to serve the scaling-up of a cell-free system;

Via commercial agreement with technical assistance :
- Industrial partner interested in cell-free expression technology: developing combined offers to increase cell-free system expertise, working as subcontractors or industrial partners working through cell systems and want to expand their offer with the cell-free expression system.

Dependent on the results, the French company and the partner will develop together a proof of concept.

There are many applications such as vaccine development, antibody development, screening-Y-diplay, in vitro diagnotics, structural biology and protein vectorization.
The French company is an expert for all these applications and allows you to focus on what matters for your projects development.
Advantages and Innovations:
The first advantage is speed. Indeed, this technology allows a protein production in 1 or 2 days when an in vivo system will take weeks or even months for some proteins.
It can also produce a wide variety of proteins, from the simplest to the most complex.
Moreover, compared to a traditional cellular expression system, the cell-free one is an open system offering the advantage of being able to incorporate additives that influence transcription, translation and folding and thus finely modulate the synthesis of the protein of interest. This system thus makes it possible to produce proteins that it would not be possible to synthesize via cellular systems. (cytotoxic proteins, complex ones...).
The cell-free system developed by the company is based on E.coli bacterial extracts. It is the most widely used and has established itself for several reasons including large-scale fermentation at low costs and high production yields.
Stage of Development:
Already on the market
IPs:
Patents granted,Exclusive Rights
CommeR Statunts Regarding IPR Status:
The company is the exclusive licensee of a patented techology based on a cell-free system to express membrane proteins in the presence of liposomes.

Partner sought

Type and Role of Partner Sought:
Any partner able to bring a technology or know-how to serve the scaling-up of a cell-free system
Industrial partner interested in cell-free expression technology
Partner to apply at EU grant application
The French company will commission a commercial agreement with technical assistance or services agreement to express, purify, characterize the proteins. Dependent on the results, the French company and the partner will develop together a proof of concept.

Client

Type and Size of Client:
Industry SME <= 10
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
French

Dissemination

Restrict dissemination to specific countries:
Belgium, Brazil, Canada, Finland, France, Germany, India, Israel, Italy, Japan, Korea, Republic Of, Norway, Poland, Singapore, Spain, Sweden, Switzerland, United Kingdom, United States, Viet Nam

Keywords

Technology Keywords:
06002006 Biología sintética
06006012 Bioprocesos
06002001 Bioquímica / biofísica
06003002 Expresión genética, investigación proteómica
06002004 Ingeniería de proteínas