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Tensioactivos catiónicos biocompatibles derivados de aminoácidos


Oferta Tecnológica
Un centro de investigación español ha desarrollado una nueva familia de tensioactivos catiónicos biocompatibles derivados de histidina con mejores propiedades de superficie, sin toxicidad y con actividad antimicrobiana y antifúngica. Estos compuestos pueden emplearse en aplicaciones alimentarias, cosméticas, biomédicas y farmacéuticas. El centro de investigación busca empresas para licenciar la patente y colaborar en actividades de investigación para desarrollar aplicaciones de los tensioactivos.


Biocompatible aminoacid cationic surfactants
A Spanish research institution has developed a new family of biocompatible cationic surfactants derived from histidine with enhanced surface properties, no toxicity and antimicrobial and antifungal activity. These compounds could be used in food, cosmetic, biomedical and pharmaceutical applications. Companies interested in patent licensing and/or in research collaboration for the development of these surfactants´ applications are sought.
Surfactants are one of the most representative chemical products, used in a great number of basic and industrial applications. However, as they can adversely affect aquatic environment, there is an increasing demand for novel environmentally friendly surfactants from renewable resources.
Surfactants derived from amino acids are compounds of great interest due to their "natural" origin, multifunctional capabilities and safety profile. A new family of cationic surfactants based on the histidine aminoacid is presented, showing an enhanced surface-activity and good antimicrobial and antifungal activity comparable to conventional cationic surfactants. These features together with their high biocompatibility make them as perfect candidates to be used in surfactant formulations.
Structurally, these compounds are built by combination of non-polar long chains with histidine to form linear and gemini amphiphilic structures. Both types of structures exhibit a good antimicrobial profile against several bacterial species both Gram-negative and Gram-positive.
The Spanish research center has broad experience in the development surfactants. The center is searching for companies that could be interested in the use of these surfactants for industrial application, under a patent license. Companies interested in this technology should carry out either by themselves or through research collaboration with this organization some further work to reach the market for tailored applications.
Advantages and Innovations:
The main advantages of this family of surfactants are:
· Simple structure based on renewable raw materials.
· Low toxicity in comparison to classical quaternary ammonium surfactants (QUATS)
· Extraordinary ability to aggregate, with micellization at low concentrations (CMC at µM range).
· Antimicrobial activity tested, showing low levels of minimal inhibitory concentration (MIC) against many Gram-positive and Gram-negative bacteria.
· Due to their emulsifying and antimicrobial capacity these surfactants could be used as alternatives to conventional surfactants in cosmetic and personal care formulations, in food preservation or in biomedical applications.
Stage of Development:
Under development/lab tested
Patent(s) applied for but not yet granted

Partner sought

Type and Role of Partner Sought:

- Type of partner sought: SME or multinational

-Specific area of activity of the partner - Manufacture of household cleaning products. Manufacturers of ingredients for cosmetic use.
Surfactants producers. Pharma industry

- Task to be performed by the partner sought: development of industrial applications to reach de market

pecific area of activity of the partner - Manufacture of household cleaning products. Manufacturers of ingredients for cleaning products

Task to be performed by the partner sought - Evaluate the technology and consider technical cooperation or licensing


Type and Size of Client:
R&D Institution
Already Engaged in Trans-National Cooperation:
Languages Spoken:


Technology Keywords:
03004011 Care, Hygiene, Beauty
03004009 Soaps, detergents
03004010 Special chemicals, intermediates
03001001 Tecnologías de limpieza