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Transporte y distribución de nucleídos radiactivos en el cuerpo humano. Modelado y simulación

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOLT20151207002
Publicado:
09/12/2015
Caducidad:
09/12/2016
Resumen:
Una universidad lituana está trabajando en modelado matemático y por computadora de procesos de transporte y distribución de nucleídos radiactivos inyectados en el cuerpo humano. El objetivo es crear modelos de transporte de sangre en las arterias y capilares, así como permitir el transporte de nucleídos radiactivos en las membranas de las células. Los modelos también pueden aplicarse para transportar moléculas de medicamentos. Se buscan socios industriales y centros de I+D con el fin de establecer acuerdos de financiación o cooperación en materia de investigación.

Details

Tittle:
Transport and distribution of radioactive nuclides in human body - modeling and simulation.
Summary:
A Lithuanian university is working on mathematical and computer modeling of the transport processes and distribution of radioactive nuclides being injected to the human body. Blood transport models in arteries and capillaries as well as transport of radioactive nuclides across membranes of cells will be done. The models can be also applied to transportation of molecules of drugs. The university is seeking for industrial partners, R-Y-D institutions for financial or research cooperation agreements.
Description:
The main purpose of the project is to have the space and time distribution of radioactive nuclides being injected to the human body. Those are necessary for the imaginary of pathologies and physiology (for diagnostics).
The same goal has to be achieved for the biological active materials (drugs, etc.) being injected to the human body. Those are useful for the study of dynamics of pharmacokinetics of complicated processes taken place in pharmacological treatment.
That´s the Research -Y- Development type project with the following working aims:
1. to test the models of processes taken place in investigation;
2. to create the special software (computer models) for the simulation of those processes.
There are the objects and processes of our researches as follows:
1. Blood transport in human body in general.
2. The features of blood transport in arteries and capillaries (including the movement of pressure pulses via arteries).
3. Transport of radioactive nuclides (and their carriers/molecules) across the membranes of various human´s organs´ cells.
4. Transport of biological active matter (drugs, molecules, micro- and nano-structures - future smart robots) via capillaries and across the membranes of cells.
The physical and mathematical models of above mentioned objects and processes have to be created. Those mathematical models have to have simple mathematical forms, or in other cases have to be interpolated via simple numerical expressions (for example - Pade approximation).
All those models have to be integrated into large "Final model" which will be used in the simulation of blood (and injected carriers with active biological/biochemical objects) transport via human body.
The Monte Carlo method has to be used for the numerical simulation of blood transport.
We underline that "Final model" is dynamic, i.e. in the permanent development phase.
During the project realization time there will be created a set of "Final models" with different levels of complexity. That R-Y-D strategy enables to shorten the products´ creation time.
There will be created the sets of working models with different complexity and accuracy for each physical (and biological) process and object.
Each process and object will be modeling by use of different approaches as follows:
1. models based on interpolation and approximation of experimental data;
2. models based on different theoretical approaches;
3. numerical models;
4. hybrid models.
The simulation results will be compared with experimental data being published in various journals, monographs and gotten via private communications.
The university research group is seeking for industrial partners, R¿D institutions from the fields of medical -Y- pharmacy, medical equipment manufactures for financial or research cooperation agreements.
Advantages and Innovations:
There are many uncertainties and difficulties in the knowledge and exact description of transport processes of blood, and various special molecules and nano-structures being injected to the human body.
The special software should be created in the frame of current project. It will be a computer based research and practical instrument for the following aims:
1) test of theoretical models in the field of blood transport in arteries and capillaries;
2) test of various theories and models of transport across membranes of cells;
3) calculate space and time distribution of injected radioactive nuclides and special active biological structures (for example drugs) in human body;
4) help in diagnostics and pharmacological treatment.
In general, there would be the practical computer based instrument in solving the problems of pharmacokinetics and medical diagnostics.
So the created products have to be the useful instruments for the pharmaceutical companies and research medical centers.
Stage of Development:
Concept stage
IPs:
Secret Know-how

Partner sought

Type and Role of Partner Sought:
Type of partner sought:
- industrial partners (large companies or SME), R-Y-D institutions from the fields of medical -Y- pharmacy, medical equipment manufactures to cooperate in developing specific software, to test and evaluate it.
Task to be performed by the partner sought:
- to test and evaluate software with a view to considering financial or research cooperation agreements.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English
Russian

Keywords

Technology Keywords:
06002001 Bioquímica / biofísica
01003006 Computer Software
06001011 Enfermedades circulatorias y del corazón
01003016 Simulaciones
06001013 Tecnología médica / ingeniería biomédica