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Universidad checa busca una compañía farmacéutica para licenciar la producción de betulina y lupeol ultra puros

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOCZ20170315001
Publicado:
30/03/2017
Caducidad:
30/03/2018
Resumen:
Una universidad checa ha desarrollado y obtenido la patente de un método de purificación de betulina y lupeol con fines farmacéuticos. La betulina, un compuesto natural, ha adquirido importancia gracias a sus propiedades antimicrobianas, antiinflamatorias, antimicóticas, antivirales, anticancerígenas y hepatoprotectoras. El proceso de extracción y purificación en cinco pasos permite conseguir grados de pureza muy altos sin utilizar equipos tecnológicos complejos. Los investigadores han desarrollado un método de producción sencillo y ecológico que garantiza un alto nivel de pureza a un coste reducido. La universidad busca compañías farmacéuticas interesadas en comprar la licencia.

Details

Tittle:
A Czech university seeks pharmaceutical company to licence production of ultra-pure betulin and lupeol.
Summary:
A Czech university has developed and patented method of purification of betulin and lupeol for pharmaceutical purposes. Natural compound betulin has gained importance for its anti-microbial, anti-inflammatory, anti-mycotic, anti-viral, anti-cancer, hepatoprotective properties. Researchers have developed a simple and environmentally-friendly production method assuring ultra-purity level at a low cost. University is seeking a pharmaceutical company interested in purchasing a license.
Description:
Researchers from a Czech university has developed a novel production method of betulin and lupeol of very high purity levels at a low cost. Betulin is a molecule naturally occurring in birch bark that is currently under investigation as a pharmaceutical compound.

It has been found that it has anti-microbial, anti-inflammatory, anti-mycotic, anti-viral, anti-cancer, hepatoprotective and many more valuable properties, which are currently valorized mostly in the cosmetic industry. However, scientists predict an increased demand especially in the field of cancer therapeutics because possible side effects are low as production costs alike.

For this reason, natural compounds, such as betulin have gained importance.
However, existing betulin purification methods bear significant disadvantages which can limit the pharmaceutical applications of the molecule. High purity grades are necessary for medical applications, but are difficult to achieve. Methods that do reach these medical standards, on the other hand, are often very expensive, time-consuming and/or environmentally unfriendly, e.g. due to the large amount of solvents used for purification and/or of other non-recyclable material.

In order to solve these problems, a novel purification method has been developed. The five step extraction and purification process achieves very high purity grades (99.5% for betulin) without the use of complicated technological equipment.

Additionally, almost 100% of the solvents used in this process are recycled, resulting in an extremely environmentally-friendly and cheap procedure. Without major changes to the current production technology, simultaneous purification of lupeol (another pharmaceutical molecule) and production of a basic source of suberin are also possible and can be of interest to a technology partner.
The institution is a research facility only and therefore they are seeking a pharmaceutical company interested in purchasing a licence based on a licensing agreement.
Advantages and Innovations:
- High degree of purity (99.5 % for betulin, more than 95 % for lupeol)
- Simple chemical procedures
- Production possible with simple and standard technological equipment
- Use of cheap solvents, that can be almost entirely recycled, resulting in a very cheap process
- Minimal use of unrecyclable materials (e.g. NaOH and HCl, common and cheap chemicals that can easily be neutralised)
- Ecological production without toxic waste thanks to circular method in which almost everything can be recycled
- Practically unlimited production capacity
Stage of Development:
Available for demonstration
IPs:
Patents granted
CommeR Statunts Regarding IPR Status:
Patent granted in the Czech Republic

Partner sought

Type and Role of Partner Sought:
University is looking for a pharmaceutical company that has a very good expertise in production of natural compounds either for its utilization or for further distribution. The company is expected to produce ultra-pure botulin, interest in production of lupeol is welcomed but not necessary. This company is expected to buy a license based on a licensing agreement.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
Czech
English

Keywords

Technology Keywords:
03004007 Pharmaceutics
06001015 Productos farmacéuticos / medicamentos