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Uso de células mesenquimales estromales de tejido adiposo para el tratamiento de la enfermedad de injerto contra el huésped (GVHD)

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOES20190424003
Publicado:
03/05/2019
Caducidad:
03/05/2020
Resumen:
Un grupo de investigación español del Sistema Nacional de Salud ha desarrollado una nueva terapia para el tratamiento o prevención de la enfermedad de injerto contra el huésped (GVHD) mediante un kit compuesto por un agente inmunosupresor y células mesenquimales estromales de tejido adiposo. La terapia mejora y facilita el procesamiento y accesibilidad del tejido donado. Las células mesenquimales estromales son a menudo conocidas por sus efectos inmunomoduladores, de ahí su interés en el tratamiento de la GVHD después de un trasplante de células madre hematopoyéticas. Este método ayuda a reducir efectos no deseados, como la alta probabilidad de recaída, infecciones o retraso en la recuperación del sistema inmunológico. El grupo de investigación busca socios del sector público y privado para continuar con el desarrollo de esta tecnología patentada. La colaboración se establecerá en el marco de un acuerdo de licencia o cooperación técnica.

Details

Tittle:
Use of mesenchymal stromal cells of adipose tissue for the treatment of graft-versus-host disease (GVHD).
Summary:
A Spanish research group of the public health system has developed a new therapy for the treatment or prevention of GVHD through a kit composed of an immunosuppressive agent and mesenchymal stromal cells of adipose tissue. The therapy improves and facilitates the processing and accessibility of the donor tissue.
A license agreement or a technical cooperation agreement for a public or private partnership for the further development of the patented technology is sought.
Description:
Graft versus host disease (GVHD) is a condition that might occur after an allogeneic transplant. In GVHD, the donated bone marrow or peripheral blood stem cells view the recipient´s body as foreign, and the donated cells/bone marrow attack the body.

Treatment often cannot provide complete healing and it takes a long time to cure the disease. The Spanish research group has developed a new therapy using mesenchymal stromal cells which improves and facilitates the processing and accessibility of the donor tissue.

Mesenchymal stromal cells are commonly known for their immunomodulatory effects, hence their interest in treating GVHD after a transplant of hematopoietic stem cells.

The Spanish research group has developed a kit composed of an immunosuppressive agent and mesenchymal stromal cells of adipose tissue.

This method helps to reduce the unwanted effects of it, such as the high probability of relapse, infections or delay for recovering the immune system.

The research group is looking for the following collaboration:
-License agreement: framework of authorizing the interested parties to use the technology.
-Technical cooperation agreement: to collaborate with other research teams, companies or foundations.
Advantages and Innovations:
- The use of mesenchymal stromal cells derived from adipose tissue improves and facilitates the processing and accessibility of the donor tissue.

- Higher cellular performance.

- More genetic stability.

-There are illustrative examples and clinical evidences that show the nature of the technique.
Stage of Development:
Prototype available for demonstration
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
PCT patent application

Partner sought

Type and Role of Partner Sought:
The research group aims to formalize a technology transfer process with public or private entities interested in the implementation of the solution, through a license agreement.

If there are some entities, such as R-Y-D centres, technology centres or specialized companies, interested in collaborating and developing further aspects of the solution, a technical cooperation agreement could be envisaged.

They already sell the plate in Spain and now they want to expand abroad.

Client

Type and Size of Client:
R&D Institution
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English
Spanish

Keywords

Technology Keywords:
06001003 Citología, cancerología, oncología
06001012 Investigaciones médicas