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Uso de glucosidasas y glucosiltransferasas para mejorar la producción de proteínas

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOSI20150311001
Publicado:
13/05/2016
Caducidad:
27/11/2016
Resumen:
Un equipo de biólogos de un instituto de investigación esloveno ofrece un proceso innovador para mejorar la producción de proteínas destinado a la industria de células vegetales. La principal ventaja es la producción más rápida y fiable de proteínas complejas. Este método permite aumentar la productividad o producir la misma cantidad de proteínas pero de forma más rápida. Se buscan empresas y centros de I+D interesados en mejorar la producción de proteínas para establecer acuerdos de cooperación técnica, comercialización con asistencia técnica o joint venture con el fin de continuar con el desarrollo, probar e implementar la innovación.

Details

Tittle:
Use of glycosidases and glycosyltransferases for enhanced protein production
Summary:
Plant biologists from a Slovenian research institute are offering an innovative procedure for enhanced protein production that can be used in plant cell industry. The main advantage is faster and reliable production of complex proteins. Companies and R-Y-D organizations interested in improved protein production are sought for technical, joint venture or commercial agreements with technical assistance.
Description:
Protein production in plants is a rapidly developing and growing area: it is more cost-effective compared to traditional methods such as microbial fermentation and animal cell cultures. Use of plant cells eliminates unwanted propagation of human pathogens or other mammalian contaminants whereas glycosylation patterns more closely resemble human proteins. Many of the plant produced proteins have already been used in clinical trials. Based on basic experimental work and the knowledge of the current state of the art, the researchers have developed a method for improved expression of heterologous proteins in plant cells. The method has already been tested in the system involving transgenic plants. Protein production based on transient expression in plants has also been tested, using the commercially available vectors for plant protein production. Using the Green fluorescent protein, researchers have shown an improved spread of vectors necessary for protein production. They have tested the production of the Norovirus coat protein (NVCP) and with the use of the invention showed higher yield of NVCP in comparison to normal production. Product is available for testing by partners, which may be from industry or research sectors involved in biotechnological protein manufacturing or protein production research, respectively. Capacities for large-scale plant production are welcome but not essential. The partners are expected to enter commercial, technical cooperation, or joint venture agreements with the aim of further developing, testing, and/or implementing the innovation.
Advantages and Innovations:
Several methods for enhanced protein production already exist, however, they enhance the production only on a cellular level. Since proteins can be produced in whole mature plants using vectors that have to spread between cells, there is a need for a way to enhance the spreading of the vectors and allow faster and higher expression of the desired protein. The invention represents the upgrade of existing methods, enabling faster, cost-effective, and more profitable protein production. With the use of the offered method the yield can be increased (in the same time frame) or the same amount of protein can be produced faster. The system provides a fast, reliable, and commercially viable way to produce complex proteins.
Stage of Development:
Under development/lab tested
IPs:
Secret Know-how

Partner sought

Type and Role of Partner Sought:
- Type of partner sought: All types - industry or research.

- Specific area of activity of the partner: Plant protein production industry or research.

- Task to be performed by the partner sought: Partners from the field of plant protein production are expected to further develop, test, and/or implement the innovation.

Client

Type and Size of Client:
R&D Institution
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English

Keywords

Technology Keywords:
06002002 Biología celular y molecular
06002007 Ensayos in vitro, experimentos
06002004 Ingeniería de proteínas
06002005 Ingeniería genética