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Uso de polimorfismos genéticos en el pronóstico auditivo de la enfermedad de Ménière

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOES20190403002
Publicado:
05/04/2019
Caducidad:
05/04/2020
Resumen:
Un grupo de investigación español del sistema de salud pública ha desarrollado una tecnología basada en polimorfismos para el diagnóstico, pronóstico y clasificación de pacientes con hipoacusia neurosensorial, y especialmente de aquellos con la enfermedad de Ménière. Hasta el momento no existe ningún método biológico que permita el diagnóstico temprano o establecer un pronóstico de la pérdida de audición a largo plazo. La enfermedad de Ménière (EM) es un trastorno crónico que afecta el oído interno caracterizado por episodios recurrentes de vértigo, inestabilidad progresiva, presión auditiva, acúfeno y pérdida de la audición. Los investigadores han demostrado la asociación de dos variantes alélicas del gen NFKB1 situadas en coordenadas genómicas específicas que determinan un alto riesgo de desarrollar hipoacusia precoz en la enfermedad de Ménière con hipoacusia neurosensorial unilateral. El grupo de investigación busca socios con el fin de establecer acuerdos de licencia o cooperación técnica.

Details

Tittle:
Use of gene polymorphism for auditive prognosis of meniere´s disease
Summary:
A Spanish research group of the public health system has developed a technology based on polymorphisms for diagnosis, prognosis and classification of patients with sensorineural hearing loss, and especially those with Meniere´s disease. Until now there has been no available biological method which allows early diagnosis or establishing a long-term hearing loss prognosis.

A license and / or technical cooperation agreement is sought.
Description:
Ménière´s disease (MS) is a chronic disorder that affects the inner ear characterized by recurrent episodes of vertigo, progressive instability, sound pressure, tinnitus and loss of hearing.

Some research studies have suggested an association between the gene TLR10 and auto immune diseases. On the other hand, the product of the gene TLR10 is an unknown ligand receptor that may play an important role in the autoimmune process and the exon 3 variants of this gene can modulate innate immune response and determine the condition of both ears. Therefore, systematic study by means of a genotyping microarray for genotyping variants previously associated with other autoimmune diseases in 186 loci (immunochip) seems to be a way to explore the maximum number of variants per sample, which improves diagnostic yield.

A wide range of medical and surgical treatments for hearing loss, and specifically for Ménière´s disease, has been proposed. All of them have yielded different results with respect to symptom remission and side effects.

Currently available treatments for hearing loss can be extremely aggressive and can put the patient´s hearing at risk. It would be important to provide a prognosis marker which will allow evaluating treatment suitability. Until now there has been no available biological method or marker which allows early diagnosis or establishing a long-term hearing loss prognosis which is useful for patient classification and makes it easier to make decisions concerning treatment and disease progression follow-up.

A Spanish hospital research group has developed a technique that uses gene polymorphism for diagnosis, prognosis and classification of patients with sensorineural hearing loss, and especially those with Meniere´s disease.

The researchers demonstrated the association of two allelic variants located in specific genomic coordinates in the NFKB1 gene that determine high risk for early hearing loss in Meniere´s disease with unilateral sensorineural hearing loss.The results obtained by using polymorphisms or single nucleotide variants allow obtaining useful information in the diagnosis and / or prognosis of a disease with sensorineural hearing loss.

The group is looking for the following collaboration:
-License agreement, in the framework of authorizing the interested parties to use the technology.
-Technical cooperation agreement, to collaborate with other research teams, companies or foundations to improve the technologies.
Advantages and Innovations:
- Two allelic variants located in specific genomic coordinates have a high frequency (0.29 and 0.42) in the general population and in patients and are very useful for establishing the prognosis with high diagnostic yield.

- The polymorphisms allow obtaining useful information in the diagnosis and / or prognosis of a sensorineural hearing loss disease.

-The identification of a more aggressive form of the disease may determine an alternative therapeutic approach that includes intratympanic drug therapy and surgery.
Stage of Development:
Available for demonstration
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
PCT patent application

Partner sought

Type and Role of Partner Sought:
The research group aims to formalize a technology transfer process with entities interested in the implementation of the solution, through a license agreement.

If there are some entities, such as R-Y-D centres, technology centres or specialized companies, interested in collaborating and developing further aspects of the solution, a technical cooperation agreement could be envisaged.

The research group already sell the technology in Spain and now they want to expand abroad

Client

Type and Size of Client:
R&D Institution
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English
Spanish

Keywords

Technology Keywords:
06001005 Diagnósticos, diagnosis
06003002 Expresión genética, investigación proteómica
06003003 Genética poblacional