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Proteínas terapéuticamente relevantes sin ligandos conocidos o ligandos pobres

Resumen

Tipo:
Demanda Tecnológica
Referencia:
TRUK20170323001
Publicado:
29/03/2017
Caducidad:
29/03/2018
Resumen:
Una empresa inglesa ha desarrollado una herramienta para predecir sitios de unión ligandables en proteínas objetivo con alta precisión y seguridad. Esta herramienta permite encontrar todos los clústeres posibles de agua fácilmente desplazables de todos los tamaños deseados en la superficie de las proteínas. La empresa busca compañías de biotecnología o grupos académicos con objetivos prometedores de gran relevancia terapéutica para establecer acuerdos de investigación o cooperación técnica.

Details

Tittle:
Therapeutically relevant proteins with no known ligands or poor ligands
Summary:
An East of England company has developed a tool to predict ligandable binding sites on protein targets with high accuracy and confidence. They seek industry or academia owning targets of high therapeutic relevance, for which there are no known, or good, ligands available. Type of cooperation: research or technical co-operation agreement.
Description:
A Cambridge startup has developed and proven the most accurate way to predict ligandable binding sites on proteins. It allows one to find all the possible easily displaceable water clusters of all desirable sizes on the proteins surface.
Given the highly successful demonstration of prediction ¬ so far (>200 active sites predicted correctly for proteins with known drugs), the method will open completely new avenues in de novo rational drug design.
The company is seeking biotechnology companies or academic groups with promising targets in the most lucrative therapeutic areas. A 3D model of the protein is needed to yield the docking sites of desired size, shape and energetic barrier.
Under a research or technical co-operation goals can be set to discover promising new drug candidates.
Technical Specification or Expertise Sought:
The targets could fall into areas such as oncology, diabetes, pain, autoimmune disease, antihypertensive, respiratory, mental health, lipid regulators etc. There is no preference in terms of protein family.
A 3D model of the target or a domain of interest is needed.

Partner sought

Type and Role of Partner Sought:
Industry and academia are sought who own highly relevant targets for which there are no well characterised ligands yet. The end goal is to discover new drugs, the exact nature of the cooperation may vary in each case.

Client

Type and Size of Client:
Industry SME <= 10
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English