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Modelo de ratón knock-in para estudiar los defectos del oído interno

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TODE20160609002
Publicado:
30/06/2016
Caducidad:
29/06/2017
Resumen:
Científicos de una universidad alemana han desarrollado un modelo de ratón knock-in para estudiar y tratar la sordera como consecuencia de los defectos del oído interno y de los defectos de hematopoyesis en trastornos inmunológicos. Concretamente ha desarrollado una cepa de ratón Gfi1P2A/P2A donde ha sido insertada una mutación puntual en el dominio SNAG que sustituye una prolina en la posición 2 del aminoácido por alanina (P2A). La universidad busca institutos de investigación o empresas con unidad de investigación en desarrollo de medicamentos para establecer acuerdos de licencia.

Details

Tittle:
Knock-in mouse model to study defects in the inner ear
Summary:
Scientists of a German university have developed a knock-in mouse model to study and treat deafness as a consequence of defects of the inner ear development as well as defects of hematopoiesis in immunological disorders. The university offers a material license agreement to research institutes or companies with a research unit active in drug development.
Description:
The Snail/Gfi1 (SNAG) family of zinc finger proteins is a group of transcriptional repressors. Gfi1 is expressed in the hematopoietic and nervous system. Consequently, mutations of Gfi1 cause defects in hematopoiesis and inner ear development.

A German university developed a Gfi1P2A/P2A mouse strain where a point mutation has been inserted in the SNAG domain that replaces a proline at amino acid position 2 by alanine (P2A). This completely abrogates the activity of Gfi1 as transcriptional repressor.

Gfi1 and its paralogue Gfi1b have overlapping, however differential functions in hematopoiesis. Loss of Gfi1 in mice affects pre-T-cell differentiation, the development of neutrophil granulocytes and inner ear hair cells, whereas in contrast loss of Gfi1b impairs the development of erythroid cells and megakaryocytes.
Therefore, Gfi1P2A/P2A mice can be used as a model to study and treat deafness as a consequence of defects of inner ear development as well as defects of hematopoiesis in immunological disorders.

The German university offers a material license agreement, e.g. to pharmaceutical industry with research units or research institues active in drug development.
Advantages and Innovations:
The Gfi1P2A/P2A knock-in mouse model is an in vivo model with significant defects of inner ear development and hematopoiesis that allows the following procedures:
- Study deafness
- Develop new approaches to treat deafness
- Study immunological disorders
Stage of Development:
Available for demonstration
IPs:
Secret Know-how

Partner sought

Type and Role of Partner Sought:
The university offers a material license agreement to research institutes or companies with a research unit that develop drugs.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
German

Keywords

Technology Keywords:
06001012 Investigaciones médicas
06001015 Productos farmacéuticos / medicamentos