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Monitor no invasivo de presión intracraneal (PIC)


Oferta Tecnológica
Una universidad londinense ha desarrollado un sensor para la medición continua no invasiva de la presión intracraneal (PIC) como alternativa a la medición invasiva. La tecnología permite la evaluación rápida y no invasiva del estado del paciente y disminuye el riesgo de efectos secundarios a la vez que reduce el coste de monitorización. El prototipo actualmente en desarrollo consiste en un monitor autónomo conectado a un ordenador portátil que graba las señales y calcula el nPIC en tiempo real. Este prototipo ha demostrado detectar cambios en la presión dentro de un modelo de tejido intracraneal in vitro. La universidad busca un socio para licenciar y desarrollar un producto de éxito destinado al mercado sanitario y establecer un acuerdo comercial con asistencia técnica.


Noninvasive Intracranial Pressure (ICP) Monitor
A London-based based University has developed a sensor for continuous non-invasive ICP measurement that replaces invasive ICP monitoring. The technology allows rapid assessment of the patient´s condition noninvasively and this reduces the significant risk of side effects whilst reducing the cost of monitoring. They are now looking for a collaboration partner to license the technology and develop a successful product for the healthcare market via a commercial agreement with technical assistance.
A London-based based University has developed a sensor for a new non-invasive system for continuous monitoring of intracranial pressure.
Head injuries are a significant cause of injury and death, with approximately 50,000 cases of severe traumatic brain injury per year in the UK alone, the majority leading to death or severe disability. Cerebral damage sustained at the time of impact is referred to as primary injury and is irreversible and best treated by prevention. Secondary brain injury occurs after the initial injury and is defined as damage arising from the body´s physiologic response to the primary injury. This may be as a result of bleeding or swelling of brain tissue. As the skull is a closed cavity containing water and other largely incompressible material, even minor swelling can cause significant increase in ICP. Initially, cerebrospinal fluid and venous blood are displaced but once these reservoirs are exhausted, small increases in pressure are transmitted directly to the brain tissue, compromising the arterial blood supply and reducing oxygen and glucose delivery to the brain tissue. This in turn results in further brain swelling which further compromises blood supply. Severe hypoxic brain injury can result, leading to irreversible brain damage. Various strategies exist to arrest or reverse this process so monitoring ICP is a vital tool in the management of severe head injuries.
The "gold standard" technique for ICP monitoring is a catheter inserted into the frontal horn lateral ventricle via a right frontal burr hole, connected to a pressure transducer via a fluid-filled catheter. It has the advantage of allowing therapeutic drainage of CSF and administration of drugs however insertion may be difficult if the ventricles are small and even if performed in a sterile environment, infections and bleeding are significant potential risks.
There has been much research in recent years to find a method for measuring intracranial pressure noninvasively (nICP) but none of these methods have found their way into clinical use as they all require considerable user intervention and are non-continuous.

The project aims to develop a new non-invasive system for continuous monitoring of intracranial pressure (ICP) via a forehead-mounted probe. Although the cranium is a closed rigid structure, interrogation using infrared light provides a potential ´window´ for monitoring cerebral haemodynamics. The probe contains infrared light sources that can illuminate the deep brain tissue of the frontal lobe, while photodetectors in the probe detect the backscattered light, which is modulated by pulsation of the cerebral arteries. Changes in the pressure surrounding the cerebral arteries affect the morphology of the recorded optical pulse, so analysis of the acquired signal using an appropriate algorithm will enable calculation of non-invasive ICP (nICP) that can be displayed continuously to clinicians.
The reported nICP could provide invaluable screening at the triage stage, indicating intracranial hypertension requiring imaging or intervention and provide effective guidance for head injury management, notably ICP-targeted treatment regimes. It could also find application in causes of non-trauma related intracranial hypertension including meningitis, hepatic encephalopathy, hydrocephalus and severe migraine.
The prototype currently in development takes the form of a stand-alone monitor connected to a notebook computer, which records the signals and calculates nICP in real time, and it has been shown to detect changes in pressure within an in vitro intracranial tissue model.
Following assessment with healthy volunteers a pilot clinical trial in patients will take place comparing the recorded nICP values with reference data recorded from an intraventricular catheter.

The University is now looking to find a collaboration partner seeking to licence and develop this technology into a product.
Advantages and Innovations:
The technology allows rapid assessment of the patient´s condition noninvasively and this reduces the significant risk of side effects whilst reducing the cost of monitoring. This makes the technology advantageous in situations where conventional assessment of intracranial pressure may not be considered because of the invasive nature of the procedure and therefore this approach could become a standard procedure in all situations where concussion has occurred.
Stage of Development:
Already on the market
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
Patents applied for and a substantial body of know how and results are available from the research team.

Partner sought

Type and Role of Partner Sought:
Collaboration partner seeking to licence and develop this technology into a commercially succesful product for the healthcare market


Type and Size of Client:
Already Engaged in Trans-National Cooperation:
Languages Spoken:


Restrict dissemination to specific countries:
China, France, Germany, Israel, Italy, Japan, Singapore, Spain, Switzerland, United Kingdom, United States


Technology Keywords:
06001012 Investigaciones médicas
05005 Micro y nanotecnología